The Weekly Mind Reader: WHO Updates Key Mental Health Guidelines

by Staff Writer
November 24, 2023 at 9:05 AM UTC

PCC has published new research that examines the relationship between psilocybin and brain chemicals such as serotonin and dopamine.

The World Health Organization (WHO) just released the latest edition of the Mental Health Gap Action Programme (mhGAP) guideline. This comprehensive update provides fresh insights and recommendations for treating mental, neurological, and substance use disorders, collectively known as MNS disorders.

MNS disorders significantly impact health and well-being worldwide. Despite their prevalence, over 75 percent of those affected lack access to necessary treatment. The mhGAP initiative targets this treatment gap, especially in non-specialized, primary healthcare settings.

What’s New in the 2023 Update

  • The guideline includes 30 updated and 18 new recommendations, alongside the 90 that already exist.
  • Anxiety disorders, increasingly common, now have a dedicated module.
  • Key suggestions include cognitive behavioral therapy (CBT) for anxiety and panic disorders, stress management techniques, and the use of Selective Serotonin Reuptake Inhibitors (SSRIs).

Broadening the Scope of Psychological Care

  • The guideline emphasizes the importance of psychological treatments across various MNS conditions.
  • New recommendations cover psychosocial support for carers of people with psychosis or bipolar disorder, as well as interventions for alcohol dependence, substance use, dementia, and neurodevelopmental disorders in children and adolescents.

Important Advice for Women of Childbearing Age

  • The updated guideline advises against using valproic acid (sodium valproate) for women who are or may become pregnant, due to risks of birth defects.
  • Women currently on valproic acid should use effective contraception and consult their doctor before planning a pregnancy.

Digital and Non-Pharmacological Interventions

  • Digitally-delivered psychological and psychosocial interventions are now more prominent, catering to a range of disorders.
  • For dementia, updated recommendations include physical exercise, CBT, cognitive stimulation therapy, and cognitive training.

Pharmacological Updates

  • New inclusions for treating psychosis, bipolar disorder, and epilepsy feature a range of antipsychotic and antiepileptic medications.

The WHO stated that the new mental health guidelines empower primary healthcare workers, including doctors and nurses, to provide effective care for people with MNS disorders. It also serves as a vital resource for health planners and managers, guiding them in developing strategies to address these critical health issues. You can find a comprehensive explanation of the recommendations here. 



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Original Research

Safety and Tolerability of Starting Aripiprazole Lauroxil With Aripiprazole Lauroxil NanoCrystal Dispersion in 1 Day Followed by Aripiprazole Lauroxil Every 2 Months Using Paliperidone Palmitate Monthly as an Active Control in Patients With Schizophrenia: A Post Hoc Analysis of a Randomized Controlled Trial

In this post hoc analysis, treatment of acutely exacerbated schizophrenia with aripiprazole lauroxil or paliperidone palmitate was well tolerated, consistent with the safety profiles of these medications.

Leslie Citrome and others

Case Report

Psilocybin and the Development of Serotonin Toxicity

This case revealed that unregulated and recreational use of psilocybin in the setting of polypharmacy demonstrates a potential risk for serotonin toxicity that should be diligently monitored.

Avisha D. Amarnani and others