Original Research

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Recently published articles about Original Research

JCP
Original Research

August 18, 2020

Lithium is an important mood disorder treatment, but the renal risks in older adults are unclear. This population-based cohort study looked at risk of renal decline with lithium vs...
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JCP
Original Research

August 18, 2020

Long-acting injectable (LAI) antipsychotics improve adherence, reduce treatment gaps, and improve clinical outcomes. This report describes the long-term safety, tolerability, and symptom trajectory with the LAI antipsychotic aripiprazole lauroxil.
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JCP
Original Research

August 11, 2020

An antidepressant medication switch often follows a failed initial trial with SSRIs. This study sought to determine the probability and timing of both response and remission and the optimal...
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PCC
Original Research

August 6, 2020

Clozapine has been associated with pneumonia, but what about other agents? This study compared pneumonia hospitalization rates for patients with a psychotic or bipolar disorder prescribed 1 of 4...
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JCP
Original Research

July 28, 2020

The Affordable Care Act of 2010, implemented in 2014, expanded access to outpatient mental health services, potentially reducing reliance on emergency departments (EDs). This study examined trends in mental...
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JCP
Original Research

July 21, 2020

What is the efficacy of antidepressants and other agents for treating cognitive impairment in adults with major depressive disorder? Review available research in this CME journal activity.
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PCC
Original Research

July 16, 2020

Clozapine is indicated for treatment-resistant schizophrenia (TRS), but many patients do not adequately respond. This study evaluated the combination of long-acting injectable antipsychotics and clozapine in TRS using various...
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JCP
Original Research

July 14, 2020

Read study discussing the treatment of MDD through modulation of dysregulated glutamate neurotransmission.
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JCP
Original Research

July 7, 2020

How many older adults receive electroconvulsive therapy (ECT) for treatment-resistant depression? Among those who receive ECT, how many finish the course? What factors might predict patients' continuation of ECT?...
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JCP
Original Research

July 7, 2020

Read the full article comparing outcomes of MDD treated with transcranial magnetic stimulation (TMS) in veterans with and without comorbid PTSD.
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JCP
Original Research

June 30, 2020

Aside from intramuscular injection, few rapidly acting pharmacotherapeutic treatments are available for acute agitation. This study examined the safety and tolerability of INP105, a drug-device combination product that allows...
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PCC
Original Research

June 25, 2020

Food supplements or probiotics have been studied as adjunctive therapy to antidepressants and psychotherapy for depression. This study assessed the effects of the combination of SAMe and Lactobacillus plantarum...
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Consensus Report on XT Use in Practice

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Figure: Graphic promoting Consensus Report on Xanomeline-Trospium; colorful net design shown with JCP logo in lower left.

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