Original Research

Recently published articles about Original Research

PCC
Inpatient Perspectives on LAIs
Original Research

Inpatient Perspectives on LAIs

September 24, 2026

In this pilot sample, patient perspectives on LAI medications during psychiatric hospitalization were heterogeneous and characterized by substantial openness and uncertainty rather than fixed resistance.
, , , et al
JCP
Psilocybin-Assisted Therapy for Bipolar II Depression
Original Research

Psilocybin-Assisted Therapy for Bipolar II Depression

September 21, 2026

Following the 10 mg session, MADRS scores improved significantly, with 4 participants (28.5%) meeting remission criteria and therefore not proceeding to the 25 mg session.
, , , et al
JCP
The Role of Chronic Anhedonia in the Relationship Between Treatment-Resistant Depression and Suicidality
Original Research

The Role of Chronic Anhedonia in the Relationship Between Treatment-Resistant Depression and Suicidality

September 21, 2026

Chronic anhedonia is significantly associated with an increased risk of suicidal ideation and attempts in patients with treatment-resistant depression.
, , , et al
PCC
Bilateral tDCS Reduces Relief Craving During Alcohol Withdrawal
Original Research

Bilateral tDCS Reduces Relief Craving During Alcohol Withdrawal

September 17, 2026

Ten sessions of bilateral transcranial direct current stimulation over the dorsolateral prefrontal cortex applied during the active withdrawal period and not modified by dependence severity significantly reduced relief craving...
, , , et al
JCP
Lumateperone as Adjunctive Therapy in Patients With Major Depressive Disorder and Anxious Distress
Original Research

Lumateperone as Adjunctive Therapy in Patients With Major Depressive Disorder and Anxious Distress

September 14, 2026

Adjunctive lumateperone 42 mg significantly improved depression and anxiety symptoms in patients with MDD with inadequate antidepressant response and anxious distress
, , , et al
JCP
Long-Acting Injectable Antipsychotics and Clozapine in Coordinated Specialty Care: Data From EPINET
Original Research

Long-Acting Injectable Antipsychotics and Clozapine in Coordinated Specialty Care: Data From EPINET

September 14, 2026

Data from the EPINET project reveal wide variation in the prescription of LAIs and clozapine across first-episode specialty care clinics.
, , , et al

Recent JCP Articles on Original Research

JCP
Life’s Essential 8 Cardiovascular Health and Suicide Mortality
Original Research

Life’s Essential 8 Cardiovascular Health and Suicide Mortality

August 19, 2026

Poor cardiovascular health status, as reflected by a low Life’s Essential 8 score, was associated with suicide mortality.
,
JCP
Persistent Gaps in Diversity of US Antidepressant Trials
Original Research

Persistent Gaps in Diversity of US Antidepressant Trials

August 12, 2026

Reporting gaps and multiple underrepresented groups persist in US antidepressant trials, limiting generalizability.
, , , et al
JCP
Time Trends in Maternal ADHD and Medication Use in Pregnancy
Original Research

Time Trends in Maternal ADHD and Medication Use in Pregnancy

August 12, 2026

The 4-fold increase in maternal ADHD in pregnancy over a 20-year period and 2-fold increase in use of stimulants before and during pregnancy underline the need for guidance on...
, , , et al

Recent PCC Articles on Original Research

PCC
Anxiety, Depression, and Substance Use in Schizophrenia
Original Research

Anxiety, Depression, and Substance Use in Schizophrenia

August 20, 2026

Early screening and management of anxiety and depressive symptoms in schizophrenia is crucial, as their presence significantly correlates with illness severity and may shape long-term functional outcomes.
, ,
PCC
Reducing Screen Time in Children With Borderline IQ
Original Research

Reducing Screen Time in Children With Borderline IQ

July 23, 2026

In this RCT, the Parent Mediated Screen Time Usage Module demonstrated significant efficacy in reducing screen time and improving associated behavioral and health outcomes among children with borderline IQ.
, , , et al
PCC
Clinical Perspectives on Internet Gaming Disorder
Original Research

Clinical Perspectives on Internet Gaming Disorder

July 23, 2026

Psychiatric providers demonstrate greater internet gaming disorder–related confidence and diagnostic familiarity than internal medicine providers, identifying a specialty-based gap in clinical preparedness.
, , , et al

Featured Original Research Research

JCP
Association of Lithium Use With Suicide and Self-Harm Among Chinese Adolescents and Adults With Bipolar Disorder
Original Research

Association of Lithium Use With Suicide and Self-Harm Among Chinese Adolescents and Adults With Bipolar Disorder

August 10, 2026

Lithium was associated with a 40% lower risk of suicidal ideation and reduced suicidal behaviors in patients with bipolar disorder
, , , et al
JCP
Pharmacokinetics of Viloxazine ER in Breast Milk
Original Research

Pharmacokinetics of Viloxazine ER in Breast Milk

August 5, 2026

This pharmacokinetic study demonstrates low drug presence in breast milk, with relative infant dose ~1%–2% of the maternal weight-based dose.
, , , et al
JCP
Exposure-Based Video Therapy for OCD and PTSD
Original Research

Exposure-Based Video Therapy for OCD and PTSD

July 29, 2026

Among patients receiving exposure-based video therapy, 67.4% achieved PTSD response, and 64.1% achieved OCD response.
, , , et al
PCC
Vision Outcomes in Children With Mental, Emotional, Developmental, or Behavioral Problems
Original Research

Vision Outcomes in Children With Mental, Emotional, Developmental, or Behavioral Problems

September 10, 2026

This study evaluated whether vision care utilization, screening/referral steps, and vision-related outcomes differ by mental, emotional, developmental, or behavioral disorder status in US children.
, , , et al
JCP
Utilizing a Smartphone Application for Perinatal Depression Screening and Care Linkages
Original Research

Utilizing a Smartphone Application for Perinatal Depression Screening and Care Linkages

September 9, 2026

The prevalence of probable perinatal depression was comparable to that in US women, demonstrating the app’s ability to identify perinatal depression.
, , , et al
JCP
Using Speech to Predict MDD and GAD During Pregnancy
Original Research

Using Speech to Predict MDD and GAD During Pregnancy

September 9, 2026

Influential speech features for prediction of MDD and GAD during pregnancy were similar to those in the general population.
, , , et al
JCP
Evaluation of Sexual Function With Adjunctive Lumateperone in Major Depressive Disorder
Original Research

Evaluation of Sexual Function With Adjunctive Lumateperone in Major Depressive Disorder

September 2, 2026

Adjunctive lumateperone 42 mg did not worsen sexual functioning and was not associated with treatment-related sexual dysfunction.
, , , et al
PCC
Intrusive PTSD Symptoms and Elevated CRP in World Trade Center Responders
Original Research

Intrusive PTSD Symptoms and Elevated CRP in World Trade Center Responders

September 1, 2026

Intrusive PTSD symptoms may contribute to systemic inflammation in WTC responders, thus targeting both PTSD symptoms and obesity/dyslipidemia may help mitigate risk for elevated systemic inflammation.
, , , et al
JCP
Obstetric Risk Associated with Stimulant vs Nonstimulant Treatment
Original Research

Obstetric Risk Associated with Stimulant vs Nonstimulant Treatment

August 26, 2026

Stimulant and nonstimulant use during pregnancy were both associated with increased risk for obstetric complications vs no medication.
,

Insightful. Evidence-based. Human-centered.

Listen Now
The Journal of Clinical Psychiatry podcast cover with Benjamin Brody, MD

Subscribe to read
more articles

Subscribe