Hyponatremia Associated With Tramadol in a Patient With Alcohol Use Disorder and Anxiety Taking Desvenlafaxine

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To the Editor: Tramadol, a weak μ-opioid agonist that also inhibits norepinephrine and serotonin reuptake, is used as an analgesic alternative to opioids like oxycodone, although it still has abuse potential, along with risks such as seizures and serotonin syndrome. A reported link exists between tramadol and hyponatremia. Presented here is a case of a woman with alcohol use disorder, on an antidepressant, who exhibited hyponatremia after a course of tramadol for musculoskeletal pain, which resolved after discontinuation of tramadol.