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Original Research October 3, 2023

Prevalence of Psychiatric Comorbidities in Patients With Neurofibromatosis

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Prim Care Companion CNS Disord 2023;25(5):23m03514

ABSTRACT

Objective: To assess the prevalence of psychiatric comorbidities in patients with neurofibromatosis.

Methods: In this cross-sectional study, we used the 2010–2014 National Inpatient Sample database. Patients ≥ 18 years of age with a primary or secondary diagnosis of neurofibromatosis and psychiatric comorbidities were queried.

Results: A total of 43,270 patients with a mean age of 48.7 years (female: 55.7%, White: 70.1%) were included in the study. Overall, psychiatric comorbidities were present in 46.5% of patients; mood disorders (22.1%) and anxiety disorders (12.2%) were the most prevalent comorbidities. Although previous studies report prevalence rates of attention-deficit/hyperactivity disorder in up to 50% of patients with neurofibromatosis, our study found that the rate was much lower at 1.10%. Female sex and non-White race were less associated with psychiatric comorbidities (odds ratio = 0.868 [P = .003] and 0.689 [P < .001], respectively). The moderate-to-extreme loss of function illness severity category was associated with 1.35-times higher odds of having psychiatric comorbidities compared to mild-to-moderate or no loss of function (P < .001). The total length of stay was similar in patients with and without psychiatric comorbidities (mean = 4.98 [95% CI, 4.72–5.24] vs mean = 4.83 [95% CI, 4.60–5.07], respectively; P = .34).

Conclusions: In adult patients with neurofibromatosis, 46.5% were found to have at least one psychiatric comorbid diagnosis. The most frequent psychiatric comorbid disorders were mood disorders and anxiety disorders. Female sex and non-White race predicted a lower likelihood of having a psychiatric disorder.

Prim Care Companion CNS Disord 2023;25(5):23m03514

Author affiliations are listed at the end of this article.

  1. Belzeaux R, Lançon C. Neurofibromatose de type 1: troubles psychiatriques et altération de la qualité de vie. (Neurofibromatosis type 1: psychiatric disorders and quality of life impairment) Presse Med. 2006;35(2 Pt 2):277–280. PubMed CrossRef
  2. HCUP-US NIS overview. HCUP-US. AHRQ website. Accessed August 2020. https://www.hcup-us.ahrq.gov/nisoverview.jsp
  3. Clinical Classifications Software Refined (CCSR). Healthcare Cost and Utilization Project (HCUP). March 2021. Agency for Healthcare Research and Quality, Rockville, MD. Accessed August 1, 2020. www.hcup-us.ahrq.gov/toolssoftware/ccsr/ccs_refined.jsp
  4. Evans DG. Neurofibromatosis type 2. Handb Clin Neurol. 2015;132:87–96. PubMed CrossRef
  5. Mansukhani SA, Butala RP, Shetty SH, et al. Familial schwannomatosis: a diagnostic challenge. J Clin Diagn Res. 2017;11(2):RD01–RD03. PubMed
  6. Le C, Bedocs PM. Neurofibromatosis. In: StatPearls. Treasure Island, FL: StatPearls Publishing; January 2022. Accessed November 2022. https://www.ncbi.nlm.nih.gov/books/NBK459329/
  7. Ghalayani P, Saberi Z, Sardari F. Neurofibromatosis type I (von Recklinghausen’s disease): a family case report and literature review. Dent Res J (Isfahan). 2012;9(4):483–488. PubMed
  8. Antinheimo J, Sankila R, Carpén O, et al. Population-based analysis of sporadic and type 2 neurofibromatosis-associated meningiomas and schwannomas. Neurology. 2000;54(1):71–76. PubMed CrossRef
  9. Gutmann DH, Ferner RE, Listernick RH, et al. Neurofibromatosis type 1. Nat Rev Dis Primers. 2017;3:17004. PubMed CrossRef
  10. Mautner VF, Kluwe L, Thakker SD, et al. Treatment of ADHD in neurofibromatosis type 1. Dev Med Child Neurol. 2002;44(3):164–170. PubMed CrossRef
  11. Rouleau GA, Merel P, Lutchman M, et al. Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature. 1993;363(6429):515–521. PubMed CrossRef
  12. Hulsebos TJ, Kenter SB, Jakobs ME, et al. SMARCB1/INI1 maternal germ line mosaicism in schwannomatosis. Clin Genet. 2010;77(1):86–91. PubMed CrossRef
  13. DeBella K, Szudek J, Friedman JM. Use of the national institutes of health criteria for diagnosis of neurofibromatosis 1 in children. Pediatrics. 2000;105(3 Pt 1):608–614. PubMed CrossRef
  14. Parry DM, Eldridge R, Kaiser-Kupfer MI, et al. Neurofibromatosis 2 (NF2): clinical characteristics of 63 affected individuals and clinical evidence for heterogeneity. Am J Med Genet. 1994;52(4):450–461. PubMed CrossRef
  15. Evans DG, Huson SM, Donnai D, et al. A clinical study of type 2 neurofibromatosis. Q J Med. 1992;84(304):603–618. PubMed
  16. Cohen JS, Levy HP, Sloan J, et al. Depression among adults with neurofibromatosis type 1: prevalence and impact on quality of life. Clin Genet. 2015;88(5):425–430. PubMed CrossRef