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A Review of Therapeutic Uses of Mirtazapine in Psychiatric and Medical Conditions

Abdulkader Alam, MD; Zoya Voronovich, BA, BS; and Joseph A. Carley, MD

Published: October 10, 2013

Article Abstract

Objective: To review the literature examining the use of mirtazapine with an emphasis on its therapeutic benefits for psychiatric patients with comorbid medical conditions.

Data Sources: MEDLINE, PsycINFO, Global Health, and AGRICOLA were searched using the terms mirtazapine OR Remeron. Limits were English language, human, year 1980-2012, treatment and prevention, and therapy.

Study Selection: Two hundred ninety-three articles were identified.

Data Extraction: Identified articles were reviewed with a focus on indications and therapeutic benefits in patients with medical comorbidities.

Results: Mirtazapine is an effective antidepressant with unique mechanisms of action. It is characterized by a relatively rapid onset of action, high response and remission rates, a favorable side-effect profile, and several unique therapeutic benefits over other antidepressants. Mirtazapine has also shown promise in treating some medical disorders, including neurologic conditions, and ameliorating some of the associated debilitating symptoms of weight loss, insomnia, and postoperative nausea and vomiting.

Conclusions: Mirtazapine offers clinicians multiple therapeutic advantages especially when treating patients with comorbid medical illness.

Prim Care Companion CNS Disord 2013;15(5):doi:10.4088/PCC.13r01525

Submitted: April 29, 2013; accepted July 9, 2013.

Published online: October 10, 2013.

Corresponding author: Abdulkader Alam, MD, 3520 5th Ave, Lower Level, Ste 1, Pittsburgh, PA 15213 (

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