Access icon

Case Report July 15, 2025

Solitary Rectal Ulcer Syndrome in a Patient Taking Fluoxetine

Prim Care Companion CNS Disord 2025;27(4):25cr03915

  1. Sadeghi A, Biglari M, Forootan M, et al. Solitary rectal ulcer syndrome: a narrative review. Middle East J Dig Dis. 2019;11(3):129–134. PubMed CrossRef
  2. Forootan M, Darvishi M. Solitary rectal ulcer syndrome: a systematic review and meta-analysis study protocol. Medicine. 2018;97(18):e0565. PubMed CrossRef
  3. Moussallem N, Haddad GC, Sbeih S, et al. Selective serotonin reuptake inhibitors and solitary rectal ulcer syndrome: a bloody relationship. Eur J Case Rep Intern Med. 2024;11(10):004826. PubMed CrossRef
  4. Vahedi H, Merat S, Rashidioon A, et al. The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study. Aliment Pharmacol Ther. 2005;22(5):381–385. PubMed CrossRef
  5. Khuituan P, Nhaemchei C, Pradab S, et al. Fluoxetine affects intestinal motility via 5-HT3 and muscarinic receptors in ex vivo mouse model. Sains Malaysiana. 2021;50(12):3647–3657. CrossRef
  6. Cheng YL, Hu HY, Lin XH, et al. Use of SSRI, but not SNRI, increased upper and lower gastrointestinal bleeding: a nationwide population-based cohort study in Taiwan. Medicine (Baltimore). 2015;94(46):e2022. PubMed CrossRef