Case Report April 11, 2024

Sudden Reduction in Caffeine Intake Increases Serum Lithium Concentration to Supratherapeutic Level: A Case Report

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Prim Care Companion CNS Disord 2024;26(2):23cr03642

  1. Mitchell DC, Knight CA, Hockenberry J, et al. Beverage caffeine intakes in the US Food Chem Toxicol. 2014;63:136–142. PubMed CrossRef
  2. Sweeney MM, Weaver DC, Vincent KB, et al. Prevalence and correlates of caffeine use disorder symptoms among a United States sample. J Caffeine Adenosine Res. 2020;10(1):4–11. PubMed CrossRef
  3. Frigerio S, Strawbridge R, Young AH. The impact of caffeine consumption on clinical symptoms in patients with bipolar disorder: a systematic review. Bipolar Disord. 2021;23(3):241–251. PubMed CrossRef
  4. Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry. 1995;37(5):348–350. PubMed CrossRef
  5. Kunitake Y, Mizoguchi Y, Sogawa R, et al. Effect of excessive coffee consumption on the clinical course of a patient with bipolar disorder: a case report and literature review. Clin Neuropharmacol. 2017;40(4):160–162. PubMed CrossRef
  6. Grandjean E. Lithium/Coca Cola interaction decreased lithium serum concentration: case report. React Wkly. 2015;(1568):184.
  7. Kralovec K, Fartacek R, Plöderl M, et al. Low serum lithium associated with immoderate use of Coca-Cola Zero. J Clin Psychopharmacol. 2011;31(4):534–544. PubMed CrossRef
  8. Ott M, Stegmayr B, Salander Renberg E, et al. Lithium intoxication: incidence, clinical course and renal function—a population-based retrospective cohort study. J Psychopharmacol. 2016;30(10):1008–1019. PubMed CrossRef
  9. Evans J, Richards J, Battisi A. Caffeine. StatPearls Internet. Published online January 2023. Accessed July 1, 2023. https://www.ncbi.nlm.nih.gov/books/NBK519490/