Volume 81 • 2020 • Number 5
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Dissociation in Pharmacokinetic Attenuation Between Central Dopamine D2 Receptor Occupancy and Peripheral Blood Concentration of Antipsychotics: A Systematic Review
Pharmacokinetics of antipsychotics are generally slower centrally than peripherally. This review examined the possible dissociation between central D2 receptor occupancy with antipsychotics and their peripheral blood concentrations.
When pregnant patients with a history of depression ask you about eating fish or using an omega-3 supplement, what do you tell them? Learn about research in the peripartum period in this journal CME activity.
Escitalopram in Adolescents With Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled Study
This study evaluated the efficacy and tolerability of escitalopram in adolescents with generalized anxiety disorder as well as the impact of variants in genes and CYP2C19 phenotypes on response and of CYP2C19 phenotypes on escitalopram pharmacokinetics.
Effect of Scheduling a Post-Discharge Outpatient Mental Health Appointment on the Likelihood of Successful Transition From Hospital to Community-Based Care
Participate in a CME activity on whether scheduling an outpatient mental health appointment is an effective and low-resource discharge planning practice.
The Affordable Care Act of 2010, implemented in 2014, expanded access to outpatient mental health services, potentially reducing reliance on emergency departments (EDs). This study examined trends in mental health-related ED visits from 2007 to 2016.
To Be Continued? Long-Term Treatment Effects of Antidepressant Drug Classes and Individual Antidepressants on the Risk of Developing Dementia: A German Case-Control Study
The effects of antidepressants and treatment duration on the progression to dementia are currently unclear. This case-control study analyzed the effects of several antidepressants with different treatment durations on the risk of developing dementia.
Acute Effects of Parent Stimulant Medication Versus Behavioral Parent Training on Mothers’ ADHD, Parenting Behavior, and At-Risk Children
This pilot study compared the effects of parent lisdexamfetamine to behavioral parent training on maternal ADHD, parenting, and child ADHD symptoms in families in which the mother had currently untreated ADHD and the young child displayed ADHD symptoms.
Efficacy and Safety of Dasotraline in Adults With Binge-Eating Disorder: A Randomized, Placebo-Controlled, Flexible-Dose Clinical Trial
Read a study evaluating dasotraline, a novel dopamine and norepinephrine reuptake inhibitor, in treating adults with binge-eating disorder (BED).
Association of Lithium Use and a Higher Serum Concentration of Lithium With the Risk of Declining Renal Function in Older Adults: A Population-Based Cohort Study
Lithium is an important mood disorder treatment, but the renal risks in older adults are unclear. This population-based cohort study looked at risk of renal decline with lithium vs valproate and whether the risk differs according to serum lithium levels.
What to Expect When Switching to a Second Antidepressant Medication Following an Ineffective Initial SSRI: A Report From the Randomized Clinical STAR*D Study
An antidepressant medication switch often follows a failed initial trial with SSRIs. This study sought to determine the probability and timing of both response and remission and the optimal duration of several second-step antidepressant treatments.
Beyond 52-Week Long-Term Safety: Long-Term Outcomes of Aripiprazole Lauroxil for Patients With Schizophrenia Continuing in an Extension Study
Long-acting injectable (LAI) antipsychotics improve adherence, reduce treatment gaps, and improve clinical outcomes. This report describes the long-term safety, tolerability, and symptom trajectory with the LAI antipsychotic aripiprazole lauroxil.
Clinical and Practical Psychopharmacology
Read a full article on the basics of conducting meta-analysis. What it is, why it is necessary, and how to interpret a forest plot.
Mean Difference, Standardized Mean Difference (SMD), and Their Use in Meta-Analysis: As Simple as It Gets
Measures and methods used in RCTs vary, so how can we combine their findings to synthesize the evidence? Read this article to gain a better understanding of meta-analysis methodology and the way in which results are pooled to draw conclusions.
Read an article on managing treatment-resistant obsessive-compulsive disorder (OCD), including optimizing the dose and trial duration.
A Simple Suggestion: Make Follow-Up Appointments for All Patients After Discharge, Especially Those With Co-Occurring Addictions
This commentary discusses the article by Smith et al on the benefits of scheduling post-discharge outpatient mental health appointments for patients released from the hospital and notes factors that may make such scheduling less likely for some patients.
In this commentary, the authors discuss the article by Bartels and colleagues on the relationship between antidepressant use and risk of incident dementia in older adults.
Read a commentary discussing the use of omega-3 fatty acids in the treatment of perinatal depression.
Read commentary on mental health needs of health care workers (HCWs), including burnout, PTSD, and suicide risk.
Letter to the Editor
Read a letter discussing psychiatric side effects that may arise with the use of Chloroquine.
This letter, which comments on a recent article by Iltis et al, discusses exclusion of suicidal patients from clinical trials for depression.
Individuals with narcolepsy may experience not only academic, social, and occupational consequences but also dangerous driving or other accidents, meaning that effective treatment is critical. Here, review the evidence on treatment strategies.
Learn from experts about recognizing symptoms and managing dementia-related psychosis (DRP) with engaging CME activities.