Schizophrenia: The Role of Dopamine and Glutamate




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Schizophrenia: The Role of Dopamine and Glutamate

Although antipsychotics are effective in treating schizophrenia, they primarily address positive symptoms of the disorder, while disabling negative and cognitive symptoms can persist. This Commentary briefly explains how dopamine dysfunction affects the symptoms of schizophrenia, why dopamine as a treatment target may limit the efficacy of medications, and how glutamate may provide possible novel targets for pharmacotherapy to more comprehensively manage the constellation of schizophrenia symptoms.

From the Division of Translational Imaging, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, New York (Dr Abi-Dargham) and Department of Psychiatry, University of California, San Diego (Dr Meyer).​

J Clin Psychiatry 2014;75(3):274–275