The article you requested is
Systematic Review of Lithium Augmentation in Depression Resistant to at Least 2 Antidepressants
Prim Care Companion J Clin Psychiatry 2009;11(4):172 [letter]
© Copyright 2014 Physicians Postgraduate Press, Inc.
Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.
To the Editor:
Refractory depression is common in
clinical practice. At least 30% of patients fail to respond to
initial antidepressant therapy.1
In patients who have failed 1
course of antidepressants, there is evidence from 9 randomized
controlled trials suggesting that approximately 50% of
treatment-refractory patients do respond to lithium augmentation
compared with placebo (p < .001).2