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Systematic Review of Lithium Augmentation in Depression Resistant to at Least 2 Antidepressants

Prim Care Companion J Clin Psychiatry 2009;11(4):172 [letter]

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To the Editor: Refractory depression is common in clinical practice. At least 30% of patients fail to respond to initial antidepressant therapy.1 In patients who have failed 1 course of antidepressants, there is evidence from 9 randomized controlled trials suggesting that approximately 50% of treatment-refractory patients do respond to lithium augmentation compared with placebo (p < .001).2