Martha M. Kato Beatriz Currier Christina M. Gomez Lacresha Hall Mercedes Gonzalez-Blanco
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Background: Metabolic syndrome, a
constellation of truncal obesity, dyslipidemia, disturbed insulin
and glucose metabolism, and hypertension, is associated with the
development of diabetes mellitus and coronary heart disease.
However, the prevalence of metabolic syndrome in Hispanic
patients with schizophrenia and whether they differ from
comparable non-Hispanic patients is uncertain.
Method: This cross-sectional study, conducted
from January 2002 to May 2002, included 48 patients with
schizophrenia who were recruited from an outpatient psychiatric
clinic. Metabolic syndrome was defined using the criteria of the
Third Report of the National Cholesterol Education Program Expert
Panel on Detection, Evaluation, and Treatment of High Blood
Cholesterol in Adults.
Results: The prevalence of metabolic syndrome
was 63% in all patients with schizophrenia. The metabolic
syndrome was present in 41% of non-Hispanic patients and in 74%
of Hispanic patients with schizophrenia. Metabolic syndrome was
present in 70% of Cuban Americans and 88% of other Hispanic
subgroups with schizophrenia. Metabolic syndrome was associated
with waist circumference (p < .05) and high-density
lipoprotein cholesterol (p < .05) in logistic regression
analysis.
Conclusions: These data suggest that
schizophrenic patients have a 3-fold greater risk to develop
metabolic syndrome than the general population. Hispanic
schizophrenic patients have a significantly greater prevalence of
metabolic syndrome than non-Hispanic schizophrenic patients (p
< .05). An increased waist circumference is the strongest
clinical correlate with metabolic syndrome in schizophrenic
patients.
Prim Care Companion J Clin Psychiatry 2004;6(2):74-77
https://doi.org/10.4088/PCC.v06n0205
© Copyright 2004 Physicians Postgraduate Press, Inc.