Psychiatrist in professional attire, poised for clinical discussion

Anita H. Clayton, MD

University of Virginia School of Medicine, Charlottesville, Virginia

  • 28Articles
  • 138.5KReads1
  • 2001–2026Active
  • 108Collaborators
  • 301Citations2

About

Anita H. Clayton, MD, affiliated with the University of Virginia School of Medicine, has published extensively on topics including major depressive disorder, sexual dysfunction, psychopharmacology, addiction, anxiety, sleep, and women's mental health. Her work covers clinical evaluations of sexual function related to antidepressant use, mechanisms of antidepressant action, and treatment considerations for depression in perimenopausal and postmenopausal women. She has contributed to research on neuroactive steroids, GABA pathways, and substance misuse in psychiatric populations. Clayton's publications span from 2001 to 2026 and include collaborations with authors such as Madhukar H. Trivedi and Angel L. Montejo.

Publications

JCP
Treatment-Resistant Depression as a Dynamic Continuum: A Consensus Panel Report
Academic Highlights ▶ Video

Treatment-Resistant Depression as a Dynamic Continuum: A Consensus Panel Report

September 23, 2026

The panelists reframe treatment-resistant depression as a dynamic continuum and provide a four-stage framework that takes clinicians from initial detection through high-acuity interventions.
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JCP
Evaluation of Sexual Function With Adjunctive Lumateperone in Major Depressive Disorder
Original Research

Evaluation of Sexual Function With Adjunctive Lumateperone in Major Depressive Disorder

September 2, 2026

Adjunctive lumateperone 42 mg did not worsen sexual functioning and was not associated with treatment-related sexual dysfunction.
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JCP
When Do Physical Symptoms After Antidepressant Cessation Reflect Pharmacodynamic versus Non-pharmacodynamic Clinical Phenomena?
ASCP Corner

When Do Physical Symptoms After Antidepressant Cessation Reflect Pharmacodynamic versus Non-pharmacodynamic Clinical Phenomena?

August 6, 2026

Focuses on descriptive symptom phenomenology and strategies to minimize discomfort during antidepressant cessation, with possible explanations for unusual, delayed, or protracted symptoms in patients for whom non-pharmacodynamic features may...
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JCP
Gepirone-ER and Sexual Function in Patients with MDD
Original Research

Gepirone-ER and Sexual Function in Patients with MDD

October 21, 2024

Rates of sexual side effects and treatment-emergent sexual dysfunction with gepirone-ER were similar to placebo and lower than sexual side effects reported for SSRIs.
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JCP
The GABA Pathway and New Clinical Trial Data in MDD and PPD
Supplement Article

The GABA Pathway and New Clinical Trial Data in MDD and PPD

March 16, 2023

Studies evaluating neuroactive steroid GABA-A receptor positive allosteric modulators demonstrate promising results for the treatment of MDD and PPD.
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JCP
Effect of Zuranolone vs Placebo in MDD
Original Research

Effect of Zuranolone vs Placebo in MDD

February 20, 2023

This phase 3 RCT found significant improvement in depressive symptoms with zuranolone beginning at day 3 of treatment.
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JCP
Original Research

Lurasidone and Sexual Function

August 7, 2018

As you probably know, sexual dysfunction is a common side effect of antidepressants and antipsychotics. This secondary analysis of an RCT examines whether the atypical antipsychotic lurasidone was linked...
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JCP
Original Research

Desvenlafaxine 50 and 100 mg/d Versus Placebo for the Treatment of Major Depressive Disorder: A Phase 4, Randomized Controlled Trial

October 28, 2014

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PCC
Article

Prevalence of Substance Misuse in New Patients in an Outpatient Psychiatry Clinic Using a Prescription Monitoring Program

January 2, 2014

The purpose of this study was to investigate the value of a prescription monitoring program in identifying prescription drug misuse among patients presenting to a resident physicians' outpatient psychiatry...
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JCP
Article

Efficacy and Safety of Desvenlafaxine 50 mg/d in a Randomized, Placebo-Controlled Study of Perimenopausal and Postmenopausal Women With Major Depressive Disorder

October 15, 2013

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JCP
Educational Activity

Understanding Antidepressant Mechanism of Action and Its Effect on Efficacy and Safety

March 15, 2012

PCC
Article

Depression or Menopause? Presentation and Management of Major Depressive Disorder in Perimenopausal and Postmenopausal Women

February 18, 2010

In this review article, examine the risk of depression onset in perimenopausal and postmenopausal women and find out how to screen for and manage depression in your perimenopausal and...
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Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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