Matheus G. Marques, MD

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota

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About

Matheus G. Marques, MD, is affiliated with the Department of Psychiatry and Psychology at the Mayo Clinic in Rochester, Minnesota. The author's publications focus on treatment-resistant depression, specifically exploring psychotherapy, pharmacotherapy, and neuromodulatory interventions. Marques has contributed to discussions on operational definitions and next-step treatment options for major depressive disorder. Collaborators include Balwinder Singh, Mark A. Frye, Ayşegül Özerdem, Brandan K. Penaluna, and Hannah K. Betcher.

Publications

JCP
Psychotherapy, Pharmacotherapy, and Neuromodulatory Interventions in Operational Definitions of TRD: Reply to De Oliveira Reis et al
Letter to the Editor

Psychotherapy, Pharmacotherapy, and Neuromodulatory Interventions in Operational Definitions of TRD: Reply to De Oliveira Reis et al

August 19, 2026

Marques et al reply to commentary on their consensus-based recommendations for treatment-resistant depression.
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JCP
Next-Step Treatment Options for Treatment-Resistant Depression
Consensus Statement

Next-Step Treatment Options for Treatment-Resistant Depression

January 21, 2026

Strong consensus emerged for augmentation with second-generation antipsychotics, TMS, and ketamine/esketamine in the base vignette. Preferences shifted to include non-augmentative antidepressants and ECT based on patient characteristics.
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