Mark A. Frye, MD

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota

JCP
Psychotherapy, Pharmacotherapy, and Neuromodulatory Interventions in Operational Definitions of TRD: Reply to De Oliveira Reis et al
Letter to the Editor

August 19, 2026

Marques et al reply to commentary on their consensus-based recommendations for treatment-resistant depression.
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JCP
Next-Step Treatment Options for Treatment-Resistant Depression
Consensus Statement

January 21, 2026

Strong consensus emerged for augmentation with second-generation antipsychotics, TMS, and ketamine/esketamine in the base vignette. Preferences shifted to include non-augmentative antidepressants and ECT based on patient characteristics.
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JCP
Ketamine Reduces Suicidality Associated ED Use in Patients With Treatment-Resistant Depression
Original Research

September 17, 2025

After the acute phase of ketamine treatment, ED visits for suicidal ideation decreased by 84%, and total ED visits for suicidality decreased by 63%.
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JCP
SSRI Discontinuation and AUD Relapse
Case Report

August 26, 2024

A man with AUD achieves sobriety on treatment with an SSRI and naltrexone, but then stops taking the SSRI to participate in a psilocybin “ceremony.” What factors contributed to...
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JCP
Ketamine vs Esketamine for TRD
Original Research

February 1, 2023

Are ketamine and esketamine equally efficacious? This observational study compares the efficacy of subanesthetic intravenous ketamine with that of intranasal esketamine for treatment-resistant depression in a real-world clinical setting.
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PCC
Review Article

December 31, 2020

Exercise, yoga, and tai chi are commonly used complementary approaches for health and wellness. This review aims to synthesize the evidence for exercise, yoga, and tai chi in the...
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PCC
Original Research

April 30, 2020

Stress is associated with the onset, maintenance, and recurrence of depression. This study aimed to investigate the feasibility of stress management and resiliency training for enhancing resiliency in a...
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JCP
Letter to the Editor

November 12, 2019

Few studies have evaluated optimal dosing of intravenous (IV) ketamine for treatment-resistant depression (TRD). This report analyzes data from previous studies of IV ketamine to assess the association between...
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JCP
Original Research

October 29, 2019

Since 2013, when DSM-5 was published, a third of the patients previously diagnosed with bipolar disorder no longer qualify as having the disorder. So what does this say about...
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JCP
Original Research

February 14, 2017

Early-onset bipolar disorder may represent a distinct phenotype with greater severity, but the genetics of it are still poorly understood. This study used candidate genetic risk score analysis to...
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JCP
Original Research

October 26, 2016

Read this article to learn whether age of onset of bipolar disorder or psychiatric illness is due to demographics or family psychiatric history.
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JCP
Original Research

August 24, 2016

Read an article exploring further evidence of the cohort effect for earlier age at onset of bipolar disorder and greater burden of psychiatric disorders.
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