Michael E. Thase, MD

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

JCP
Original Research

December 1, 2020

Adjunctive pimavanserin can reduce depressive symptoms and improve function in patients with major depression and inadequate antidepressant response. This analysis evaluated the effects of adjunctive pimavanserin on sleep/wakefulness disturbances.
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JCP
Original Research

October 31, 2019

This study sought to ascertain the extent that pharmacogenetic testing can inform treatment decisions among patients with treatment-resistant depression whose medications are subject to gene-drug interactions—read the article to...
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JCP
Original Research

September 24, 2019

The use of atypical antipsychotics as adjunctive treatment for nonresponsive depression is limited by their side effects. This study explores whether pimavanserin can be both an efficacious and tolerable...
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JCP
Meta-Analysis

March 19, 2019

Computer-assisted cognitive-behavior therapy (CCBT) allows clinicians to deliver evidence-based care to more patients than would be possible with standard CBT. This meta-analysis sought to determine if additional clinician support...
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JCP
Educational Activity

February 20, 2019

Most people who experience a depressive episode are greatly impaired by it. No one-size-fits-all therapy is available, and most patients require multiple treatment steps. Check out this CME activity...
JCP
Commentary

July 5, 2018

This commentary by Michael E. Thase, MD, discusses the article "Antipsychotic Medication Treatment Patterns in Adult Depression" by Gerhard et al.
PCC
Article

March 1, 2018

Can a computer program help primary care clinicians and their patients in treatment of depression? This systematic review of eight studies of computer-assisted cognitive-behavior therapy found that computerized delivery...
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JCP
ASCP Corner

February 21, 2018

JCP
Academic Highlights

November 28, 2017

Many of your patients with depression also experience anxiety symptoms, and addressing these symptoms is a crucial part of successful treatment. Explore this free Academic Highlights activity to learn...
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JCP
Meta-Analysis

September 19, 2017

Acute sleep deprivation is one of the most rapid antidepressant interventions known; however, its benefits are usually short-lived. This meta-analysis synthesizes the existing data on acute sleep deprivation in...
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JCP
Original Research

July 11, 2017

Quetiapine has the greatest evidence of efficacy for bipolar II depression, but it is also associated with metabolic side effects. This study compared psychotherapy plus placebo or plus pharmacotherapy....
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JCP
Original Research

April 26, 2017

Do depressed patients with comorbid panic disorder have antidepressant treatment side effect profiles that differ from those of patients without panic disorder? Check out this article to review the...
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