Shih-Jen Tsai, MD

  • 26Articles
  • 139.4KReads1
  • 1997–2025Active
  • 59Collaborators
  • 276Citations2

Publications

JCP
Klotho and Matrix Metalloproteinase-9 Levels and Their Association with Inhibitory Dyscontrol in Adolescents with First-Episode Major Affective Disorders
Original Research

Klotho and Matrix Metalloproteinase-9 Levels and Their Association with Inhibitory Dyscontrol in Adolescents with First-Episode Major Affective Disorders

July 16, 2025

Adolescents with bipolar disorder and those with MDD had significantly lower Klotho levels compared with the control group; those with bipolar disorder had the highest MMP-9 levels, followed by...
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JCP
Risk of Alzheimer’s Disease and Vascular Dementia in Patients With Peripheral Vestibular Disorders
Original Research

Risk of Alzheimer’s Disease and Vascular Dementia in Patients With Peripheral Vestibular Disorders

June 2, 2025

The authors found that peripheral vestibular disorders are a risk factor for dementia, regardless of psychiatric comorbidities.
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JCP
Appetite Hormone Regulation Biotypes of Major Affective Disorders
Original Research

Appetite Hormone Regulation Biotypes of Major Affective Disorders

April 9, 2025

Three appetite hormone regulation biotypes were identified among patients with major affective disorders. They were associated with proinflammatory cytokine profiles and executive function, with one biotype group showing poorer...
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JCP
Parental Severe Mental Disorders and Deaths in Offspring With MDD
Original Research

Parental Severe Mental Disorders and Deaths in Offspring With MDD

March 31, 2025

Parental-Severe-Mental-Disorder-All-Cause-Suicide-Mortalities-Adolescent-Young-Adults-Major-Depressive-Disorder
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JCP
Effects of Low-Dose Ketamine Infusion on Hopelessness and Suicidal Thoughts
Original Research

Effects of Low-Dose Ketamine Infusion on Hopelessness and Suicidal Thoughts

July 8, 2024

A single infusion of low-dose ketamine resulted in a brief (~4 hour) yet significant reduction in hopelessness.
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JCP
Excess Mortality Associated With Schizophrenia
Original Research

Excess Mortality Associated With Schizophrenia

September 13, 2023

Females, patients with connective tissue disorders, and those aged 20 years or younger were especially impacted by the effect of schizophrenia on increasing mortality.
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JCP
Treatment Resistance in Late-Onset MDD
Original Research

Treatment Resistance in Late-Onset MDD

March 23, 2022

This study investigated the association of physical versus psychiatric comorbidities with treatment resistance in older people with late-onset major depressive disorder.
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JCP
Original Research

Alopecia Areata and Dementia

October 26, 2021

Alopecia areata (AA) shares a similar inflammatory signature with dementia, and AA’s negative psychosocial impact may lead to poor social engagement, a risk factor for dementia. This nationwide cohort...
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JCP
Original Research

Coaggregation of BD-I/BD-II With Major Psychiatric Disorders

September 7, 2021

Etiologic differences between bipolar I and II disorders have been challenged recently. This study used a large nationwide database to determine the risk of familial aggregation of specific psychiatric...
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JCP
Postpartum Depression and Psychosis and Subsequent Mental Disorders
Original Research

Postpartum Depression and Psychosis and Subsequent Mental Disorders

July 27, 2021

In the West, postpartum depression and psychosis have been linked to later mental disorders in both mothers and children, but does this hold true for Asian populations? This analysis...
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JCP
Original Research

OCD and Dementia Risk

May 11, 2021

Case reports suggest a link between obsessive-compulsive disorder (OCD) and dementia, but this association has received little research. The current study investigated dementia risk among OCD patients using a...
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JCP
Original Research

Happiness During Low-Dose Ketamine Infusion Predicts Treatment Response

November 10, 2020

Can we determine which patients will respond to ketamine just by observing their mood during the infusion? This study evaluated antidepressant outcomes with ketamine in 71 patients, focusing on ...
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