Warren Cheng, BA
Northeast Ohio Medical University in Rootstown, Ohio
Rounds in the General Hospital
Clozapine, Xanomeline-Trospium, and Catatonia
August 11, 2026
Abrupt clozapine discontinuation during a cross-taper to xanomeline/trospium chloride can trigger catatonia. Learn how overlapping cholinergic mechanisms complicate this transition and how to manage withdrawal-induced catatonia.