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Consensus Statement and Research Needs: The Role of Dopamine and Norepinephrine in Depression and Antidepressant Treatment

David J. Nutt, MD, PhD; David S. Baldwin, DM, FRCPsych; Anita H. Clayton, MD; Rodney Elgie; Yves Lecrubier, MD; Angel L. Montejo, MD, PhD; George I. Papakostas, MD; Daniel Souery, MD, PhD; Madhukar H. Trivedi, MD; and Andre Tylee, MD, FRCGP, MRCPsych

Published: June 15, 2006

Article Abstract

During a special session, the faculty identified several specific areas related to the role of dopamine and norepinephrine in depression and antidepressant treatment that either warrant the clinician’s attention or are in need of more research. Areas of interest include fatigue and lethargy in depression, treatment strategies for treatment-resistant depression, the somatic presentation of depression, neurobiology of fatigue and its role in determining treatment, symptom rating scales, and sexual side effects. In addition, the faculty discussed the importance of patient psychoeducation and self-management as well as the ways in which disease models of depression affect treatment.

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