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Letter to the Editor

Hypomania Associated With Mirtazapine Augmentation of Sertraline

Cesar A. Soutullo, Susan L. McElroy, and Paul E. Keck, Jr.

Published: June 15, 1998

Article Abstract

Sir: Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA). Its novel mechanism of action involves α2-adrenergic autoreceptor and heteroreceptor blockade, enhancing serotonin (5-HT) and norepinephrine release; and 5-HT2, 5-HT3, and histamine H1 antagonism. Because mirtazapine blocks 5-HT2 and 5-HT3 receptors, 5-HT1-mediated transmission is enhanced.

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