This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.


Can Monoamine-Based Therapies Be Improved?

Mark A. Demitrack, MD

Published: February 1, 2002

Article Abstract

Monoamine-based therapies that selectively target serotonin, norepinephrine, or dopamine uptakeare effective as antidepressants. However, many depressed patients do not achieve remission withthese single-action agents. Treatment strategies that target more than one neurotransmitter, eitherthrough augmentation, combination treatment, or the development of single agents with dual or triplereuptake mechanisms, may prove to be even more effective than traditional antidepressants and meritfurther research.

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 63

Quick Links: