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Letter to the Editor

Sexual Dysfunction Associated With Mirtazapine: A Case Report

MAJ Timothy R. Berigan and Jeffrey S. Harazin

Published: June 15, 1998

Article Abstract

Sir: The recently released antidepressant mirtazapine has a unique pharmacologic action that makes it unlike any other antidepressant on the U.S. market today. It is purported to assert its antidepressant effects by antagonizing the presynaptic α2– adrenergic autoreceptors and heteroreceptors on norepinephrine and serotonin presynaptic axons as well as acting as a postsynaptic antagonist of 5-HT2 and 5-HT3. By virtue of this 5-HT2 and 5-HT3. blockade, the side effects typically associated with the SSRIs such as nausea, vomiting, diarrhea, insomnia, and sexual dysfunction tend to occur less often with mirtazapine than with placebo.

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