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Educational Activity

Using Mechanism of Action to Choose Medications for Treatment-Resistant Depression

Michael E. Thase, MD (Chair), and Thomas L. Schwartz, MD

Published: September 23, 2015

Article Abstract

Remission rates for depression continue to be low, and for many patients, complex treatment regimens are needed for optimal response. Many physicians do not fully understand how and why depression medications work or which ones will complement each other. This CME Webcast covers the different mechanisms of action of current pharmacotherapeutic options for depression, both monotherapy and adjunctive medications, and shows clinicians how to use their understanding of mechanisms of action to choose the most effective treatment strategy for their patients, especially those with treatment-resistant or difficult-to-treat depression.

From the Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia (Dr Thase) and the Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York (Dr Schwartz).

This CME activity is expired. For more CME activities, visit
Find more articles on this and other psychiatry and CNS topics:
The Journal of Clinical Psychiatry
The Primary Care Companion for CNS Disorders


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