Original Research

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Recently published articles about Original Research

PCC
Irritability and Geriatric Depression
Original Research

January 30, 2025

The objective of this study was to determine the frequency of irritability in a sample of geriatric individuals and its clinical relevance in the detection of depression.
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JCP
ECT for Psychotic vs Nonpsychotic Depression
Original Research

January 29, 2025

Patients with major depression with psychotic features had higher response rates to ECT than those without psychotic features and similar rates of adverse cognitive effects. After adjustment for confounders,...
, , , et al
PCC
COVID’s Mental Health Impact on Primary Care Health Workers
Original Research

January 28, 2025

This study assessed the prevalence of anxiety, depression, insomnia, and perceived stress, as well as the factors that mediate stress with depression and anxiety, among rural health care workers.
, , , et al
JCP
Esketamine Nasal Spray vs Quetiapine ER in Treatment-Resistant Depression
Original Research

January 27, 2025

Esketamine was associated with significantly larger improvements in work productivity loss and related costs compared to quetiapine, suggesting greater benefits from patient well-being and employer perspectives.
, , , et al
JCP
Psychological Challenges of Adults with SMI during the COVID-19 Pandemic
Original Research

January 22, 2025

Adults with SMI diagnosed with COVID-19 and those who sheltered in place during lockdown experienced more severe psychological distress compared to those not diagnosed with COVID-19.
, , , et al
JCP
Sulforaphane Added to Antipsychotics for Negative Symptoms of Schizophrenia
Original Research

January 20, 2025

Add-on high dose sulforaphane may reduce negative symptoms in patients with schizophrenia, although the clinical significance of this reduction needs further evaluation.
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PCC
Impact of Lemborexant on Daytime Functioning
Original Research

January 16, 2025

Improved insomnia symptoms with lemborexant treatment may translate into improved daytime functioning.
, , , et al
PCC
Suicide-Specific Cognitions in US Military Veterans
Original Research

January 14, 2025

This study examined data from a large, nationally representative sample of US veterans to determine the prevalence and correlates of high chronic suicide risk.
, , , et al
JCP
BI 1358894 in Borderline Personality Disorder
Original Research

January 13, 2025

Although the primary endpoint was not met, BI 1358894 was well-tolerated with no increase in self-harm or suicidality.
, , , et al
JCP
Cardiovascular Risk Factors and Second Generation Antipsychotics
Original Research

January 8, 2025

Despite well-documented cardiovascular disease (CVD) morbidity and mortality, CVD risks among people with severe mental illness who use antipsychotics are common and frequently untreated.
, , , et al
JCP
IV Hydroxyzine vs Haloperidol for Delirium
Original Research

January 6, 2025

Hydroxyzine showed a significantly higher rate of delirium improvement than haloperidol, with no significant difference in the time to improvement.
, , , et al
JCP
Olanzapine/Samidorphan Effects on Weight Gain
Original Research

January 2, 2025

Treatment with a combination of olanzapine and samidorphan was associated with less weight gain and reduced risk of reaching ≥7% or ≥10% gain in body weight versus olanzapine over...
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