This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Case Report

A Case of Delusional Parasitosis Treated in an Outpatient Setting Using the Collaborative Care Model

Patrick A. Ho, MD, MPHa,b,*; Breanne Anstine, LISWb; and Kevin Johns, MDa,b

Published: October 27, 2022

Prim Care Companion CNS Disord 2022;24(6):22cr03318

To cite: Ho PA, Anstine B, Johns K. A case of delusional parasitosis treated in an outpatient setting using the collaborative care model. Prim Care Companion CNS Disord. 2022;24(6):22cr03318.
To share:

© 2022 Physicians Postgraduate Press, Inc.

aThe Ohio State University College of Medicine, Columbus, Ohio
bDepartment of Psychiatry, Wexner Medical Center, The Ohio State University, Columbus, Ohio
*Corresponding author: Patrick A. Ho, MD, MPH, 1 Medical Center Dr, Lebanon, NH 03756 (



Delusional parasitosis is a rare manifestation of delusional disorder, somatic type.1 Delusional parasitosis is characterized by a fixed, false belief that one’s body is infested with living organisms without objective evidence to support this.2 Treatment typically occurs in an outpatient setting with low-dose antipsychotic medications and frequent, validating therapeutic interactions.3 While such treatment for delusional parasitosis is well-documented in typical outpatient settings, there are currently no reports of this condition being treated using the collaborative care model (CoCM). We aim to present the case of a woman suffering from delusional parasitosis who was treated in a CoCM setting.

Case Report

Ms A is a 70-year-old woman with a past medical history of depression, alcohol use disorder in remission, diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea. She had a longstanding history of depression, which was acutely exacerbated approximately 1 year prior to presentation when she began to believe that she had “mites” in her skin. She had been evaluated by 2 dermatologists, neither of whom found evidence of infestation. She noted that she would often pick mites out of her skin but that they would “dehydrate” quickly, and she could thus never bring them to an office visit for evaluation. At this time, the patient was being treated for depression by her primary care physician (PCP) with oral duloxetine 60 mg/d and bupropion 300 mg/d. Ms A’s PCP referred her to the CoCM behavioral health team consisting of a licensed independent social worker, attending psychiatrist, and psychiatry fellow who collaborate with the patient’s PCP, who continued to prescribe all medications. While the CoCM behavioral health team managed Ms A’s behavioral health problems, regular collaborative discussions with the patient’s PCP allowed management of these problems in the context of medical comorbidities.

The CoCM social worker initially assessed and subsequently communicated with the patient as needed and discussed the case with the psychiatrists and PCP monthly. The psychiatrists provided management recommendations to guide the PCP’s prescribing. The CoCM psychiatry team initially recommended cross-titration off bupropion in favor of aripiprazole. This cross-titration was completed, with the patient remaining on oral aripiprazole 5 mg/d. At 1-month follow-up with the CoCM team, the patient reported having a more “positive attitude” regarding her symptoms. At 3-month follow-up, Ms A felt that her symptoms had remitted. As she met her care goal, Ms A’s CoCM case was closed, and her PCP was encouraged to reconsult CoCM if needed.


Delusional parasitosis is a condition that is often very distressing to patients and can be challenging to treat.4 Treatment typically involves a combination of psychotropic medications and frequent, validating outpatient visits. This can sometimes present a challenge, as the fixed nature of the patient’s delusions may invite confrontation to which the patient may not respond well, and some dermatologists and PCPs may not feel comfortable prescribing antipsychotic medications. While antipsychotic medications have been found to be effective in the treatment of delusional parasitosis,5 a study6 estimated that only approximately 3% of dermatologists feel comfortable prescribing antipsychotic medications. CoCM utilizes systematic psychiatric assessment in primary care settings with a nonphysician care manager who can perform longitudinal monitoring, treatment interventions, and coordination of care.7 Additionally, a psychiatrist reviews all cases with a care manager to provide further recommendations. CoCM, while not a new intervention, has a great deal of evidence for the management of depression and anxiety but has not been as widely studied in other psychiatric conditions.8

Delusional parasitosis can be difficult to treat and is often treated in primary care, dermatology, or psychiatry outpatient settings. However, considering that patients in primary care or dermatology clinics may be hesitant to accept referral to an outpatient psychiatrist, collaborative interventions deliverable in primary care or dermatology settings could add value in the care of these patients. CoCM represents an opportunity for collaboration between disciplines in the treatment of delusional parasitosis.9


Delusional parasitosis is a disorder that can prove very difficult to treat and may best be treated using a multidisciplinary approach. The collaborative and multidisciplinary nature of CoCM may lend itself well to the care of patients with this disorder and should be considered as a potential innovative approach to its treatment. CoCM is also an opportunity to expand collaboration between psychiatry, dermatology, and primary care.

Published online: October 27, 2022.
Relevant financial relationships: None.
Funding/support: None.
Additional information: Information has been de-identified to protect patient anonymity.

Volume: 24

Quick Links:


Buy this Article as a PDF