Volume 80 • 2019 • Number 4
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Clinical and Practical Psychopharmacology
Anticholinergic Drug Exposure and the Risk of Dementia: There Is Modest Evidence for an Association but Not for Causality
What's the link between anticholinergic drugs and dementia? Dr Andrade discusses a recent large study that examined this question and then considers the nature of this link, citing 4 methodologic aspects that influence interpretation of the findings.
Antidepressant Drugs and the Risk of Hip Fracture in the Elderly: Is There More to It Than Confounding by Indication?
Dr Andrade considers the findings of observational studies indicating a higher risk of hip fracture in older people who take antidepressants—and whether confounding by indication can fully explain the results.
With a high prevalence of metabolic syndrome among young patients with bipolar disorder, the need for early screening, prevention, and intervention for its components is great.
Longitudinal Trajectories of Psychotic-Like Experiences and Their Relationship to Emergent Mental Disorders Among Adolescents: A 3-Year Cohort Study
Psychotic-like experiences in adolescence can be predictors of developing subsequent psychosis. This longitudinal study examined the likelihood of this progression as well as other factors that contribute to this risk of developing a psychiatric disorder.
Trajectories of Suicidal Ideation During 12 Weeks of Escitalopram or Nortriptyline Antidepressant Treatment Among 811 Patients With Major Depressive Disorder
When are your depressed patients having suicidal thoughts during antidepressant treatment and are their ideations persistent? Identifying which 1 of the 5 distinct trajectory classes each patient is in can help guide treatment.
New Coprescription of Opioids and Benzodiazepines and Mortality Among Veterans Affairs Patients With Posttraumatic Stress Disorder
Opioids and benzodiazepines are commonly coprescribed, but the risk of death associated with this practice is unknown. This study compared mortality among patients coprescribed these agents with those prescribed medications from either or neither class.
The Relevance of Sex in the Association of Synthetic Cannabinoid Use With Psychosis and Agitation in an Inpatient Population
Compared to men, women have higher sensitivity to cannabinoids. Does this sex difference extend to synthetic cannabinoids as well? Read the findings of this retrospective chart review to learn more.
Women who take mood stabilizers have a greater risk of placenta-mediated pregnancy complications. But are the mood stabilizers themselves responsible for this higher risk? This study explores that question.
Risk Score for Predicting Mortality in People With Dementia: A Nationwide, Population-Based Cohort Study in Taiwan With 11 Years of Follow-Up
Using an 11-year follow-up of a population-based retrospective cohort, a risk score model identified 11 acute and chronic factors to predict mortality for dementia patients. A suitable care plan can now be formulated with patients and caregivers.
Research on antipsychotics and stroke risk has focused on elderly demented patients, who have higher stroke risk than younger patients.Â This study compared stroke risk between typical and atypical antipsychotics in non-demented, non-elderly individuals.
A Randomized Placebo-Controlled Trial of Omega-3 and Sertraline in Depressed Patients With or at Risk for Coronary Heart Disease
Adjunct treatment with the omega-3 fatty acid eicosapentaenoic acid (EPA) has been shown to increase antidepressant efficacy. This study examined whether adding EPA to sertraline improved response in depressed patients with coronary heart disease.
Sleep problems are associated with higher risk of suicidal behavior. Since adolescents have increased risk for both suicidal behavior and sleep problems, this study explored the relationship of specific sleep problems to suicidal behavior and self-harm.
Prevalence and Predictors of Benzodiazepine Monotherapy in Patients With Depression: A National Cross-Sectional Study
Although depression guidelines discourage monotherapy with benzodiazepines, patients with depression continue to receive benzodiazepine monotherapy. This study evaluates the prevalence and predictors of benzodiazepine in depressed patients.
Screening for Perinatal Anxiety Symptoms in Obstetric Settings Is Recommended, and Proper Provider Training Is Essential
This commentary discusses the findings and implications of a recent meta-analysis by Fawcett et al on anxiety disorders during pregnancy and the postpartum period.
The Prevalence of Anxiety Disorders During Pregnancy and the Postpartum Period: A Multivariate Bayesian Meta-Analysis
Addressing anxiety disorders in pregnant women and new mothers is important, especially given the potential effects on offspring. Do you know which disorders are most common? Read this meta-analysis to learn more.
Benzodiazepine Use During Pregnancy Alone or in Combination With an Antidepressant and Congenital Malformations: Systematic Review and Meta-Analysis
Is prenatal benzodiazepine use associated with an increased risk of congenital malformations? What about concurrent use of a benzodiazepine and an antidepressant? Does the trimester have an effect? See what these reviewers found.
Transdermal delivery is an alternative to oral routes of drug administration. This delivery route has several innate advantages that may benefit patients with CNS disorders—read this Expert Commentary to learn more.
Staging Treatment Intensity and Defining Resistant Depression: Historical Overview and Future Directions
To optimize treatment choices for patients with treatment-resistant depression (TRD), TRD should be defined accurately and unambiguously. This review examines extant descriptions and staging models of TRD and posits directions for future definitions.
Cognitive Assessment of Alzheimer’s Disease and Dementias in Clinical Practice: Pragmatics of Brief Instruments and Neuropsychological Evaluation
Meaningful benefits can be derived from the evaluation of cognition in older adults when there is possible cognitive impairment and dementia. Here, experts explain how brief cognitive assessment tools and neuropsychological evaluations can aid diagnosis and inform a management plan.
Letter to the Editor
Berrouiguet and colleagues reply to the letter "Beyond Statistical Significance: An Underrated Suicide Prevention Intervention" by MartÃnez-Alés et al.
In this letter to the editor, MartÃnez-Alés and colleagues comment on the recent article "Combining Postcards, Crisis Cards, and Telephone Contact Into a Decision-Making Algorithm to Reduce Suicide Reattempt" by Vaiva et al.