Volume 82 • 2021 • Number 1
This editorial reflects on the unique challenges of the past year and recognizes peer reviewers for JCP in 2020.
How Much Is the Debate Over Antidepressant Efficacy and Safety in Bipolar Depression an Artifact of Study Methodologies?
This editorial discusses a recent study of citalopram in bipolar depression and revisits the long-held assumption that antidepressants lead to poor outcomes in bipolar disorder.
Outcomes of Neuroleptic Malignant Syndrome With Depot Versus Oral Antipsychotics: A Systematic Review and Pooled, Patient-Level Analysis of 662 Case Reports
Is the advantage of longer-term medication release with long-acting injectable antipsychotics offset by an increased risk of more prolonged and severe neuroleptic malignant syndrome? This systematic review and pooled analysis address that question.
Since the association of the inflammatory biomarker hs-CRP with depression is unclear, alternative inflammatory biomarkers of depression are needed. This study examined the association between the inflammatory biomarker GlycA and depressive symptoms.
Efficacy and Safety of HP-3070, an Asenapine Transdermal System, in Patients With Schizophrenia: A Phase 3, Randomized, Placebo-Controlled Study
Transdermal asenapine administration may address unmet needs in patients with schizophrenia, including improved adherence. This phase 3 study assessed efficacy and safety of HP-3070, an asenapine transdermal system (patch), in adults with schizophrenia.
Citalopram for Acute and Preventive Efficacy in Bipolar Depression (CAPE-BD): A Randomized, Double-Blind, Placebo-Controlled Trial
Antidepressants are widely used to treat bipolar illness, though their effectiveness in this disorder has not been established. This randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of citalopram in bipolar depression.
Because COVID-19 is associated with a risk of death and lack of effective treatments, patients are at risk of developing PTSD. This cohort study assessed the prevalence of PTSD in outpatients, hospitalized patients, and those requiring an ICU stay.
Effect of Adjunctive Pimavanserin on Sleep/Wakefulness in Patients With Major Depressive Disorder: Secondary Analysis From CLARITY
Adjunctive pimavanserin can reduce depressive symptoms and improve function in patients with major depression and inadequate antidepressant response. This analysis evaluated the effects of adjunctive pimavanserin on sleep/wakefulness disturbances.
Prevalence and Correlates of Caregiver-Reported Mental Health Conditions in Youth With Autism Spectrum Disorder in the United States
People with autism spectrum disorder (ASD) experience health conditions at above-average rates, but how are they affected by concurrent mental disorders? This analysis of survey data looks at the prevalence of specific conditions such as ADHD and anxiety.
Effects of Long-Acting Injectable Paliperidone Palmitate on Clinical and Functional Outcomes in Patients With Schizophrenia Based on Illness Duration
Although long-acting injectable (LAI) antipsychotics show benefit in the early stages of schizophrenia, they are mostly used later in the illness. This study assessed clinical and functional improvement with paliperidone LAI at different illness durations.
Research on suicidality in the Arab region is scarce. This study explored recent and present suicidality as well as demographic characteristics associated with such attempts among residents in this region looking for depression information online.
Sociodemographic Factors, Health Behaviors, and Biological Indicators Associated With Suicide Mortality Among Young Adults in South Korea: A Nationwide Cohort Study Among 15 Million Men and Women
Sociodemographic factors, health behaviors, and biological indicators as risks for suicide are relatively understudied among young adults. This study sought to determine which nonpsychiatric factors might be associated with suicide among young people.
Cost-Effectiveness of Routine Screening for Autoimmune Encephalitis in Patients With First-Episode Psychosis in the United States
Autoimmune encephalitis (AE) is a highly treatable neurologic condition that can cause psychosis. This study estimated the cost-effectiveness of routine screening for AE compared with clinically targeted screening in first-episode psychosis patients.
Antipsychotic Medication Prescriptions for Homeless and Unstably Housed Veterans in the Veterans Affairs Health Care System
Many homeless and unstably housed (HUH) adults have severe mental illness managed with antipsychotic medications. This study examined antipsychotic medication use and correlates of antipsychotic medication prescriptions among HUH versus non-HUH veterans.
Toward Targeted ECT: The Interdependence of Predictors of Treatment Response in Depression Further Explained
Several clinical variables assumed to predict electroconvulsive therapy (ECT) outcome in major depressive disorder are interrelated. This study tries to disentangle this interdependence to distill the most important predictors of ECT treatment success.
Risk Factors for Reattempt and Suicide Within 6 Months After an Attempt in the French ALGOS Cohort: A Survival Tree Analysis
Understanding risk factors for suicidal behavior is crucial for the development of effective prevention plans. Do anxiety disorders or alcohol use disorder play a role? Learn more in this CME activity.
Associations Between ADHD Medication Use in Pregnancy and Severe Malformations Based on Prenatal and Postnatal Diagnoses: A Danish Registry-Based Study
Do you have patients who take ADHD medication and are planning a pregnancy? How do you respond to questions of safety? This journal CME activity offers evidence.
Building Resilience Among Frontline Health Care Workers: Strategies to Consider for Implementing Evidence-Based Practices
This commentary discusses a recent brief report by Pietrzak et al and lists 3 strategies that health care systems could use to improve mental health support for frontline health care workers during the COVID-19 pandemic.
Clinical and Practical Psychopharmacology
HARKing, Cherry-Picking, P-Hacking, Fishing Expeditions, and Data Dredging and Mining as Questionable Research Practices
In this article, Dr Andrade helps readers identify several types of statistical analysis that violate scientific principles and that researchers may knowingly—or unknowingly—engage in.
Two recent meta-analyses found little effect of N-acetylcysteine augmentation in MDD or bipolar depression, although some past research has indicated its efficacy. In this article, Dr Andrade takes a closer look at whether the evidence supports its use.
The question of whether, and when, antidepressants are appropriate in bipolar disorder is a hotly debated topic. This ASCP Corner article summarizes the key concepts with greatest relevance for clinical decision-making.
Long-acting injectable antipsychotics are effective for preventing relapse in schizophrenia, but in-person administration of them is a challenge during a pandemic. This report describes how a clinic successfully reduced in-person injections by 40%.
Psychological Resilience in Frontline Health Care Workers During the Acute Phase of the COVID-19 Pandemic in New York City
Read this brief report examining stressors as well as factors associated with resilience among New York City health care workers in the acute phase of the COVID-19 pandemic.
Letter to the Editor
In this letter to the editor, the authors comment on a Clinical and Practical Psychopharmacology article recently published in JCP.
Here, Dr Andrade replies to a letter to the editor regarding a recent Clinical and Practical Psychopharmacology column on use of baclofen in alcohol use disorder patients.
In this letter to the editor, Finsterer and colleagues comment on an article by Manu et al.
This letter comments on methodologic aspects of a recent study by Uher and colleagues.
In this letter to the editor, Dr Uher and colleagues reply to Drs Swami and Mishra.
How to Evaluate Patients and Educate Them About Self-Examinations for Tardive Dyskinesia Between Appointments
In brief videos, Drs McEvoy and Nierenberg discuss symptoms of tardive dyskinesia, how to observe patients (whether in person or via telemedicine), and how to educate patients and families about TD.