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Recently published articles about Difficult to Treat Depression
Original Research
Intravenous Ketamine for Treatment-Resistant Depression
September 12, 2022
The clinical effectiveness of ketamine for suicidal ideation and treatment-resistant depression outside of controlled clinical trials is unclear. This article reports clinical outcomes of a large cohort treated with...
Original Research
Young Adult Depression, Antidepressant Prescriptions, and Therapy Intensification in the US
September 6, 2022
This study evaluated the temporal trend in young adult depression, prescription patterns of first- and second-line antidepressants, and factors influencing therapy intensification for depression stratified by sex.
Brief Report
Deep Brain Stimulation and Treatment-Resistant Depression
January 20, 2022
Treatment-resistant depression exhibits varying degrees of refractoriness. In this report, the authors discuss experimental treatments such as deep brain stimulation for depressed patients who are resistant to treatment.
Meta-Analysis
Effect of rTMS on Suicidal Ideation in Treatment-Resistant Depression
January 18, 2022
Repetitive magnetic transcranial stimulation (rTMS) has been established as an efficacious treatment for MDD. This meta-analysis looked at its effects on suicidal ideation in depressed patients across the lifespan.
Original Research
Continuation MST for Treatment-Resistant Depression
October 19, 2021
Magnetic seizure therapy (MST) has shown promise as an alternative to electroconvulsive therapy for acute treatment-resistant depression (TRD). This study examines the efficacy of MST as a continuation treatment...
