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Recently published articles about Difficult to Treat Depression

JCP
Review Article

June 4, 2019

To optimize treatment choices for patients with treatment-resistant depression (TRD), TRD should be defined accurately and unambiguously. This review examines extant descriptions and staging models of TRD and posits...
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PCC
Article

July 26, 2018

How common is it for patients with pharmacologically treated depression to not receive adequate doses of antidepressant medications? Is treatment-resistant depression incidence overestimated in database studies that do not...
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JCP
Original Research

May 29, 2018

Treatment-resistant depression (TRD), broadly defined, is depression not in remission after treatment. About a third of depressed patients lack response to at least one adequate treatment. But how can...
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JCP
Original Research

May 1, 2018

Ketamine has shown promise in treating depression and posttraumatic stress disorder (PTSD) individually. This article examines repeated ketamine infusions for individuals with comorbid treatment-resistant depression and PTSD—read it to...
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JCP
Original Research

February 27, 2018

Although electroconvulsive therapy is the most robust acute treatment for MDD, nearly one-third of patients don' t respond to it—but why? This study investigated C-reactive protein and interleukin-6, both...
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JCP
Original Research

February 20, 2018

Read why treatment resistant depression, even compared to MDD, poses a significant direct and indirect cost burden to US employers and employment status.
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JCP
Original Research

January 23, 2018

The Maudsley Staging Method has been validated as a way to quantify and predict depression course and outcome, but its generalizability to a community-based population had not yet been...
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JCP
Original Research

December 19, 2017

Up to 50% of patients with systemic inflammation from ongoing physical illness develop major depressive disorder. This nationwide, population-based study in 2 independent cohorts explored the relationship between inflammation...
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JCP
Original Research

December 5, 2017

Read a study measuring the accuracy of machine learning in predicting treatment resistant depression (TRD).
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PCC
Article

October 19, 2017

Research on behavioral activation teletherapy is limited. Learn about a brief behavioral activation teletherapy program for depression and anxiety in a study describing results among low-income, real-world primary care...
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PCC
Letter to the Editor

March 9, 2017

Ketamine infusions can provide relief of depression with suicidal ideation within hours. However, the high cost, expertise required to administer the infusion, and dissociative effects that may occur at...
JCP
Original Research

February 28, 2017

Read a randomized control trial examining whether adding cognitive-behavioral therapy (CBT) for Pharmacotherapy-Resistant Depression improves outcomes.
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