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A patient with undiagnosed cyclothymia, with a decade of depression, anxiety, and inattention, had severe worsening of depression and anxiety after a high-dose, lay-administered psilocybin session.

Xanomeline-trospium shows activity against negative symptoms of schizophrenia, but current evidence does not establish superiority over other antipsychotics.

Psychiatric consultation can address the shame associated with hospitalization for rectal insertion of foreign objects, provide harm-reduction counseling, facilitate outpatient referral, and manage countertransference reactions among staff.

DT120 (lysergide) and SNTX-2643 are advancing as investigational GAD treatments at different stages of development, with neither yet approved by the FDA.