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The authors present 2 cases of intranasal tapentadol dependence marked by rapid tolerance and significant physical and psychological issues.

Dr Culpepper, Editor in Chief, outlines manuscript selection criteria for the PCC, prioritizing clinical relevance to primary care and frontline psychiatric settings, and thanks peer reviewers for their service.

The authors examine the historical context of stress, the neurobiological mechanisms of conserved transcriptional response to adversity and stress, and how yoga practices counteract its effects.

In patients receiving MBC for bipolar disorder in primary care, treatment changes were more common in the presence of elevated symptoms.