This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.
Letter to the Editor
Colon Perforation and Peritonitis Associated With Clozapine
Published: December 31, 2000
Letter to the Editor
Sir: The antipsychotic clozapine can cause many adverse effects, most notably agranulocytosis and seizures. In addition to such effects on the hematopoietic system and the central nervous system, clozapine can seriously affect the gastrointestinal system: deaths from bowel obstruction, severe fecal impaction, and necrotizing colitis have been reported. To increase awareness of clozapine’s potent effects on the gut, we describe a case of a perforated colon and peritonitis associated with clozapine. Our patient survived, albeit with a markedly reduced quality of life.
Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.
Quick Links: