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Discussion on Brain Mechanisms of Social Anxiety Disorder

Published: May 21, 1998

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Dr. Ballenger: What is known about dorsal raphe serotonergic control of striatal dopamine neurons?
Professor Nutt: The conventional idea is that the 5-HT input is inhibitory, for several reasons. One is that if you increase 5-HT with selective serotonin reuptake inhibitors (SSRIs), you can get symptoms that are similar to what you get with dopamine blockade, so akathisia and dystonias, as reported with some SSRIs, are effects similar to those found when blocking dopamine D2 receptors with neuroleptics.

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Volume: 59

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