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Academic Highlights

Enhancing Treatment Response in Depression.

Philip T. Ninan, MD; Maurizio Fava, MD; and Kerry J. Ressler, MD, PhD

Published: September 1, 2004

Article Abstract

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Kerry J. Ressler, MD, PhD, opened with the statement that the symptoms of major depressive disorder can be viewed as a result of brain circuit dysfunction. Three classes of molecules involved in depressive symptoms include the monoamines, which regulate broad functioning of neural circuits; neuropeptides, which mediate behavior-specific components of neural circuits; and neurotrophins, which allow for plasticity of the brain and maintenance of neural circuits.

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