Background: The authors investigated whether 6 weeks of treatment with fluvoxamine would decrease the anxiogenic response to the 35% CO2 challenge in 11 patients with DSM-IIIR panic disorder with agoraphobia.
Method: The patients underwent a 35% CO2 challenge at baseline and again after 6 weeks of fluvoxamine treatment.
Results: The anxiogenic effect of CO2 was significantly (p < .05) reduced during fluvoxamine treatment.
Conclusion: The results suggest a relationship between the anxiogenic effect of CO2 and the therapeutic effect of fluvoxamine.
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