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Letters to the Editor

Treating Schizophrenia With Comorbid Depressive or Demoralization Symptoms

Ira D. Glick, MD; Samuel G. Siris, MD; and John M. Davis, MD

Published: March 14, 2008

Article Abstract

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Sir: Two of us (I.D.G., J.M.D.) recently had an articlepublished in the Journal1 which suggested that concomitantpsychotropic medications (CPMs) may not improve outcomeof antipsychotic monotherapy for stabilized patients withnonacute schizophrenia. In the article, we stated that "to ourknowledge, there have been no published reports of prospectiveinvestigations of systematic discontinuation of concomitantmedication in this patient population (i.e., nonacute,stabilized patients with schizophrenia)."1(p1262)As it happens, one prospective, double-blind, randomized,controlled study of the discontinuation of adjunctive antidepressantmedication, during maintenance-phase treatment hadbeen conducted.2‘ ‹’ ‹

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