The Primary
Care Companionfor CNS Disorders

Volume 27 • 2025 • 6

Review Article

Analysis of Gender-Affirming Surgeries to Improve Gender Dysphoria and Quality of Life in the United States

Prim Care Companion CNS Disord 2025;27(6):23r03677

Jatminderpal S. Bhela, MD; Sundas Saboor, MPH; Maliha Ansari, MBBS; Manpreet Bhullar, MBBS; Akhilesh Agarwal, MBBS; Arpana Ashok, MBBS; Mihir Amin, MD; Rashmi Subhedar, MD; Sana Javed, MBBS; Tejasvi Kainth, MD; Garima Yadav, MD; Kaushal Shah, MD, MPH; Zeeshan Mansuri, MD, MPH; Shailesh Jain, MD, MPH

Original Research

Impact of Patient Suicide on Mental Health Professionals

Prim Care Companion CNS Disord 2025;27(6):25m03995

Shipra Singh, MD; Nitin B. Raut, MD; Akansha Bhardwaj, MD; Yogender Malik, MD, DNB

Rounds in the General Hospital

Psychological Sequelae of Drone Attacks

Prim Care Companion CNS Disord 2025;27(6):25f04056

Joseph L. Bonvie, PsyD; Sofia E. Matta, MD; Serhii Andriichenko, MD; Ihov Slobodian, MD; Andrea Leiner, APRN; Yulia Brockdorf, RD; Theodore A. Stern, MD

Rounds in the General Hospital

Screening for and Managing the Sequelae of Toxic Exposures in Veterans

Prim Care Companion CNS Disord 2025;27(6):25f04018

Sofia E. Matta, MD; Joseph L. Bonvie, PsyD; James K. Rustad, MD; Mara Joy, FNP-C; Jill Rainone, CNP; Christina L. La Croix, DO, CDR USN; Tony S. Quang, MD, JD; Theodore A. Stern, MD

Rounds in the General Hospital

Talking to Your Patients About Alcohol, Marijuana, and Substance Use During Pregnancy

Prim Care Companion CNS Disord 2025;27(6):25f04012

Charlotte S. Hogan, EDM, MD; Chirag M. Vyas, MBBS, MPH; Gregory T. Woods, MD; Suena H. Massey, MD; Theodore A. Stern, MD

Rounds in the General Hospital

Rage: Differential Diagnosis, Evaluation, and Management

Prim Care Companion CNS Disord 2025;27(6):25f04033

Sofia E. Matta, MD; Andrea C. DeSimone, DO; Daniel R. Fisher, MD; Michalla B. Braford, DO; Katerina Mastronardi, DO; Jacob M. Weber, MD; Theodore A. Stern, MD

Rounds in the General Hospital

Facilitating Academic Success for Practicing Clinicians

Prim Care Companion CNS Disord 2025;27(6):25f03994

James K. Rustad, MD; Patrick A. Ho, MD, MPH; Linda J. Herrera Santos, MD, PhD; Jeong Hoo Lee, MD; Theodore A. Stern, MD

Rounds in the General Hospital

Treatment Nonadherence: Sequelae of Using Digital Technologies to Circumvent Hospital Dietary Restrictions

Prim Care Companion CNS Disord 2025;27(6):25f04031

Emma Zhao, MD; Brandon Wilson, MD; Michael Harrington, MD; Patrick A. Ho, MD, MPH; James K. Rustad, MD; Theodore A. Stern, MD

Rounds in the General Hospital

Collaboration Between Primary Care Providers and Mental Health Professionals: Rationale and Clinical Practice

Prim Care Companion CNS Disord 2025;27(6):25f03977

Jonah N. Cohen, PhD; Jeong Hoo Lee, MD; Ashwini Nadkarni, MD; James K. Rustad, MD; Theodore A. Stern, MD

Rounds in the General Hospital

Talking to Your Patients About Inflammatory Bowel Diseases: A Guide for Primary Care Providers

Prim Care Companion CNS Disord 2025;27(6):25f04010

Ashwini Nadkarni, MD; Elizabeth N. Madva, MD; Samuel I. Kohrman, MD; Jennifer Jolivert, MD; Aarya Rajalakshmi, MBBS, MD; Alexandra Fuss, PhD; Franklin King IV, MD; Theodore A. Stern, MD

Case Report

Tetrabenazine-Induced Rapid-Onset Suicidality in an Adolescent With Schizophrenia and Obsessive-Compulsive Disorder

Prim Care Companion CNS Disord 2025;27(6):25cr04045

Sathyaseelan Manivel, MD; Suganya B.S. Priyadharshini, MD

Case Report

Machine Madness: A Case of Artificial Intelligence Psychosis Co-Occurring With Substance-Induced Psychosis

Prim Care Companion CNS Disord 2025;27(6):25cr04059

Matthew R. Caldwell, MD; Patrick A. Ho, MD, MPH

Case Report

From Varenicline to Neuroleptic Malignant Syndrome: The Complex Effects of Smoking Cessation on Dopamine Regulation

Prim Care Companion CNS Disord 2025;27(6):25cr04004

Monica A. Nava Frenier, MD; Maxwell F. Lydiatt, MD

Case Report

Transient Loss of Consciousness in an Adolescent With Pathological Intoxication

Prim Care Companion CNS Disord 2025;27(6):25cr04007

Rishab Yadav, MD; Shruti Kumar, DNB; Shobit Garg, MD

Case Report

Kratom Withdrawal: A Case Report and Review of Epidemiology, Incidence, and Prevalence

Prim Care Companion CNS Disord 2025;27(6):25cr04043

Brandon J. Goodwin, DO; Moiuz Chaudhri, MD; Ankur Jain, DO; Taraneh Alahdadi, MS; Amitpal Vohra, DO; Sakhi Patel, DO; Hanna Brancaccio, BA; Fatima Mossolem, MS; Christian Kaunzinger, MD

Case Report

Clozapine-Induced Corrected QT-Interval Prolongation and Relationship With Serum Clozapine Concentration

Prim Care Companion CNS Disord 2025;27(6):25cr04052

Hirofumi Hirakawa, MD, PhD

Case Report

The Fine Line: Balancing Pragmatism and Ethics in the Management of Acute Mania

Prim Care Companion CNS Disord 2025;27(6):25cr04034

N. A. Uvais, MBBS, DPM, FRSPH, FRSB

Case Report

Bupropion for Treatment of Depression and Narcolepsy in a Postpartum Patient

Prim Care Companion CNS Disord 2025;27(6):25cr04036

Jisselly Sanchez Salcedo, MD; Kayleigh A. Watson, MD; Bradley T. Miller, MD; Mackenzie McGinn, MD; Monica P. Yusishen, MD; Drew C. Casey, MS; Meaghan N. Holub, BS

Case Report

Unstable Lithium Levels in a Bodybuilder With Bipolar Disorder: The Impact of Sodium Intake and Anabolic Steroid Use

Prim Care Companion CNS Disord 2025;27(6):25cr04028

Nicholas S. McDuffee, MA, BS; Aren A. Forster, BA; Kaushal Shah, MD, MPH, MBA

Case Report

Diagnostic Challenges in Distinguishing Huntington Disease From Tardive Dyskinesia

Prim Care Companion CNS Disord 2025;27(6):25cr04020

Anuhya Kotta, BS; Sahar Ashraf, MD; Mehreen Khan, MD; Pavithra Wickramage, DO; Michael Rafferty, MD

Case Report

Neurological and Psychiatric Manifestations of Cerebral Arteriovenous Malformation: A Case of Hemichorea and Depression

Prim Care Companion CNS Disord 2025;27(6):25cr03999

Astha Jain, MD; Shobit Garg, MD, DPM; Rohitash Sharma, MD

Case Report

Treatment of Schizophrenia and Comorbid Diphenhydramine Dependence With Clozapine

Prim Care Companion CNS Disord 2025;27(6):25cr03998

Marina Trefethen, PharmD, BCPP

Case Report

Serotonin Syndrome With Quetiapine, Rizatriptan, Gabapentin, and Propranolol

Prim Care Companion CNS Disord 2025;27(6):25cr03919

Lawrance Mukona, MD; Victoria Nobari, DO; Julia Kaster, DO; Madeline Schmiedeknecht, OMS-IV

Case Report

A Case of Benzodiazepine-Induced Neurologic Dysfunction Following Chronic Use

Prim Care Companion CNS Disord 2025;27(6):25cr04026

Danielle M. Krohn, BS; Alëna A. Balasanova, MD

Case Report

Psychosis, Posttraumatic Stress, and Suicidality Obscure Comorbid Autism Spectrum Disorder: A Report on Differential Diagnosis

Prim Care Companion CNS Disord 2025;27(6):25cr04022

Michael R. Capawana, PhD, ABPP

Case Report

Multiple System Atrophy Presenting as Late-Onset Psychosis

Prim Care Companion CNS Disord 2025;27(6):25cr04005

Spencer Milanak, BA; Kaushal Shah, MD; Jacob Bhatti, BS; Sahil Munjal, MD

Case Report

Clozapine Withdrawal–Induced Catatonia

Prim Care Companion CNS Disord 2025;27(6):25cr04014

Brandon Wilkinson, DO; Winston Snyder, DO; Zainab Shah, DO; Sarah Heming, DO

Case Report

Religious Preoccupation in Psychosis and Adolescence

Prim Care Companion CNS Disord 2025;27(6):25cr04013

Sneha Pamulapati, DO; Paige A. Bimberg, MD; Rachel R. Beery-Mathews, DO; Magdoline Daas, MD

Case Report

Probable Lumateperone-Associated Urticarial Rash in a Patient With Schizophrenia

Prim Care Companion CNS Disord 2025;27(6):25cr04024

Neetu Garg, MBBS; Shobit Garg, MD, DPM; Mohan Dhyani, MD

Letter to the Editor

Screening for Psychosis Among Individuals With Rare Genetic Disorders That Confer Risk for Schizophrenia-Like Phenotypes

Prim Care Companion CNS Disord 2025;27(6):25lr04037

Mark Ainsley Colijn, MD, MSc, FRCPC, UCNS

Letter to the Editor

Semaglutide for Alcohol Use Disorder

Prim Care Companion CNS Disord 2025;27(6):25lr04040

Vania Modesto-Lowe, MD, MPH; Deanna Sgambato, DMS, MHS, PA-C

Letter to the Editor

Revisiting Dr Vidya Sagar’s Culturally Adaptive Innovative Approaches to Mental Health Care in India

Prim Care Companion CNS Disord 2025;27(6):25lr04023

Gurvinder Pal Singh, MD

Volume 27 • 2025 • 6

Review Article

Analysis of Gender-Affirming Surgeries to Improve Gender Dysphoria and Quality of Life in the United States

Original Research

Impact of Patient Suicide on Mental Health Professionals

Rounds in the General Hospital

Psychological Sequelae of Drone Attacks

Screening for and Managing the Sequelae of Toxic Exposures in Veterans

Talking to Your Patients About Alcohol, Marijuana, and Substance Use During Pregnancy

Rage: Differential Diagnosis, Evaluation, and Management

Facilitating Academic Success for Practicing Clinicians

Treatment Nonadherence: Sequelae of Using Digital Technologies to Circumvent Hospital Dietary Restrictions

Collaboration Between Primary Care Providers and Mental Health Professionals: Rationale and Clinical Practice

Talking to Your Patients About Inflammatory Bowel Diseases: A Guide for Primary Care Providers

Case Report

Tetrabenazine-Induced Rapid-Onset Suicidality in an Adolescent With Schizophrenia and Obsessive-Compulsive Disorder

Machine Madness: A Case of Artificial Intelligence Psychosis Co-Occurring With Substance-Induced Psychosis

From Varenicline to Neuroleptic Malignant Syndrome: The Complex Effects of Smoking Cessation on Dopamine Regulation

Transient Loss of Consciousness in an Adolescent With Pathological Intoxication

Kratom Withdrawal: A Case Report and Review of Epidemiology, Incidence, and Prevalence

Clozapine-Induced Corrected QT-Interval Prolongation and Relationship With Serum Clozapine Concentration

The Fine Line: Balancing Pragmatism and Ethics in the Management of Acute Mania

Bupropion for Treatment of Depression and Narcolepsy in a Postpartum Patient

Unstable Lithium Levels in a Bodybuilder With Bipolar Disorder: The Impact of Sodium Intake and Anabolic Steroid Use

Diagnostic Challenges in Distinguishing Huntington Disease From Tardive Dyskinesia

Neurological and Psychiatric Manifestations of Cerebral Arteriovenous Malformation: A Case of Hemichorea and Depression

Treatment of Schizophrenia and Comorbid Diphenhydramine Dependence With Clozapine

Serotonin Syndrome With Quetiapine, Rizatriptan, Gabapentin, and Propranolol

A Case of Benzodiazepine-Induced Neurologic Dysfunction Following Chronic Use

Psychosis, Posttraumatic Stress, and Suicidality Obscure Comorbid Autism Spectrum Disorder: A Report on Differential Diagnosis

Multiple System Atrophy Presenting as Late-Onset Psychosis

Clozapine Withdrawal–Induced Catatonia

Religious Preoccupation in Psychosis and Adolescence

Probable Lumateperone-Associated Urticarial Rash in a Patient With Schizophrenia

Letter to the Editor

Screening for Psychosis Among Individuals With Rare Genetic Disorders That Confer Risk for Schizophrenia-Like Phenotypes

Semaglutide for Alcohol Use Disorder

Revisiting Dr Vidya Sagar’s Culturally Adaptive Innovative Approaches to Mental Health Care in India

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Volume 27 • 2025 • 6

Review Article

Analysis of Gender-Affirming Surgeries to Improve Gender Dysphoria and Quality of Life in the United States

Original Research

Impact of Patient Suicide on Mental Health Professionals

Rounds in the General Hospital

Psychological Sequelae of Drone Attacks

Screening for and Managing the Sequelae of Toxic Exposures in Veterans

Talking to Your Patients About Alcohol, Marijuana, and Substance Use During Pregnancy

Rage: Differential Diagnosis, Evaluation, and Management

Facilitating Academic Success for Practicing Clinicians

Treatment Nonadherence: Sequelae of Using Digital Technologies to Circumvent Hospital Dietary Restrictions

Collaboration Between Primary Care Providers and Mental Health Professionals: Rationale and Clinical Practice

Talking to Your Patients About Inflammatory Bowel Diseases: A Guide for Primary Care Providers

Case Report

Tetrabenazine-Induced Rapid-Onset Suicidality in an Adolescent With Schizophrenia and Obsessive-Compulsive Disorder

Machine Madness: A Case of Artificial Intelligence Psychosis Co-Occurring With Substance-Induced Psychosis

From Varenicline to Neuroleptic Malignant Syndrome: The Complex Effects of Smoking Cessation on Dopamine Regulation

Transient Loss of Consciousness in an Adolescent With Pathological Intoxication

Kratom Withdrawal: A Case Report and Review of Epidemiology, Incidence, and Prevalence

Clozapine-Induced Corrected QT-Interval Prolongation and Relationship With Serum Clozapine Concentration

The Fine Line: Balancing Pragmatism and Ethics in the Management of Acute Mania

Bupropion for Treatment of Depression and Narcolepsy in a Postpartum Patient

Unstable Lithium Levels in a Bodybuilder With Bipolar Disorder: The Impact of Sodium Intake and Anabolic Steroid Use

Diagnostic Challenges in Distinguishing Huntington Disease From Tardive Dyskinesia

Neurological and Psychiatric Manifestations of Cerebral Arteriovenous Malformation: A Case of Hemichorea and Depression

Treatment of Schizophrenia and Comorbid Diphenhydramine Dependence With Clozapine

Serotonin Syndrome With Quetiapine, Rizatriptan, Gabapentin, and Propranolol

A Case of Benzodiazepine-Induced Neurologic Dysfunction Following Chronic Use

Psychosis, Posttraumatic Stress, and Suicidality Obscure Comorbid Autism Spectrum Disorder: A Report on Differential Diagnosis

Multiple System Atrophy Presenting as Late-Onset Psychosis

Clozapine Withdrawal–Induced Catatonia

Religious Preoccupation in Psychosis and Adolescence

Probable Lumateperone-Associated Urticarial Rash in a Patient With Schizophrenia

Letter to the Editor

Screening for Psychosis Among Individuals With Rare Genetic Disorders That Confer Risk for Schizophrenia-Like Phenotypes

Semaglutide for Alcohol Use Disorder

Revisiting Dr Vidya Sagar’s Culturally Adaptive Innovative Approaches to Mental Health Care in India

Consensus Report on XT Use in Practice

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