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Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

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PCC
High-dose Veterinary AMP Dependence
Case Report

High-dose Veterinary AMP Dependence

January 27, 2026

A 41-year-old man self-administered mega-doses of veterinary adenosine monophosphate over an extended period and experienced intense withdrawal and psychological symptoms after discontinuation.
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PCC
Basal Ganglia Stroke With Lower Motor Neuron Features
Case Report

Basal Ganglia Stroke With Lower Motor Neuron Features

January 22, 2026

A 60-year-old man exhibited left-sided toe walking and right-sided weakness despite previous history of left sided basal ganglia stroke, challenging the notion that adult toe walking is a hallmark…
, , , et al
PCC
Benign Ethnic Neutropenia and Clozapine
Case Report

Benign Ethnic Neutropenia and Clozapine

January 22, 2026

This case highlights the importance of recognizing benign ethnic neutropenia to prevent unnecessary clozapine discontinuation.
, , , et al
PCC
Depression Remission in Parkinson Disease With iTBS
Case Report

Depression Remission in Parkinson Disease With iTBS

January 20, 2026

Two cases demonstrate the potential for intermittent theta burst transcranial magnetic stimulation to rapidly reverse treatment-resistant depression in patients with Parkinson disease.
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PCC
Lithium-Induced Rash: Unveiling the Dermatological Dilemma
Case Report

Lithium-Induced Rash: Unveiling the Dermatological Dilemma

January 20, 2026

A 32-year-old woman recently diagnosed with bipolar affective disorder developed lithium-induced rash that did not recur on rechallenge.
, , , et al
PCC
Skin Picking in Profound Intellectual Disability
Case Report

Skin Picking in Profound Intellectual Disability

January 15, 2026

A 39-year-old woman with profound intellectual disability and delayed developmental milestones presented with late-onset severe dermatillomania.
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PCC
LSD-Induced Catatonia in an Adolescent
Case Report

LSD-Induced Catatonia in an Adolescent

January 13, 2026

A 16-year-old boy experienced catatonia associated with lysergic acid diethylamide use.
, , , et al
PCC
Treatment and Referral for AUD in Primary Care
Rounds in the General Hospital

Treatment and Referral for AUD in Primary Care

January 13, 2026

Explore which treatments are best for your patients with alcohol use disorders and when you should refer for specialized psychological or pharmacologic interventions.
, , , et al
PCC
Cotard Syndrome in Schizophrenia
Case Report

Cotard Syndrome in Schizophrenia

January 8, 2026

A 42-year-old woman with schizophrenia and multiple prior hospitalizations presented with worsening psychosis and physical aggression toward her mother.
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PCC
Kratom-Induced Psychosis
Letter to the Editor

Kratom-Induced Psychosis

January 8, 2026

The author comments on the complexity of substance-induced presentations, particularly those related to newly available psychoactive substances such as kratom.
PCC
Family Support for Patients With Substance Use Disorders
Original Research

Family Support for Patients With Substance Use Disorders

January 6, 2026

Family inclusion in SUD treatment improves patient outcomes, but provider referrals remain limited; health care providers should prioritize connecting patients with available family support resources.
, , , et al
PCC
Semaglutide for Alcohol Use Disorder
Letter to the Editor

Semaglutide for Alcohol Use Disorder

January 1, 2026

The authors explore potential mechanisms underlying the relationship between GLP-1 agonists and AUD as well as studies evaluating semaglutide for AUD.
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