Psychotic Disorders

Psychotic disorders, including schizophrenia, are characterized by delusions, hallucinations, and disorganized thinking. The Journal of Clinical Psychiatry offers comprehensive insights into these disorders, from their neurobiological underpinnings to evidence-based therapeutic strategies. Our expert editors ensure content is both actionable and holistic, aiding psychiatrists in offering comprehensive care to individuals with psychotic disorders.

Recently published articles about Psychotic Disorders

PCC
Calcineurin Inhibitor–Induced Psychosis
Case Report

February 17, 2026

The authors report a case of delayed and recurrent calcineurin inhibitor–induced psychosis with both tacrolimus and cyclosporine, highlighting the need to better understand host vulnerability and risk stratification.
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Psychosis Soars in Younger Generations
news

February 10, 2026

A large study finds that psychosis diagnoses are rising sharply – and appearing earlier – among younger generations.
JCP
Clinical pearls of early use of Xanomeline–Trospium in the in-patient setting with Michael Halassa MD, PhD
Podcast

February 10, 2026

Dr. Halassa shares clinical insights on xanomeline-trospium for inpatient schizophrenia, addressing negative symptoms and treatment-resistant cases.
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JCP
Developing Algorithmic Psychiatry with Michael Halassa MD, PhD
Podcast

January 27, 2026

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Where Autoantibodies Strike in Anti-NMDAR Encephalitis
news

January 26, 2026

A new study shows that antibodies in anti-NMDAR encephalitis target exposed hotspots on NMDA receptors, explaining synaptic disruption.
JCP
Rethinking Amisulpride: Could N-Methylation Result in a New and Even Better Antipsychotic?
ASCP Corner

January 26, 2026

This article will familiarize US clinicians with amisulpride’s history and data, and the rationale behind development of LB-102, an N-methylated analogue of amisulpride.
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Recent JCP Articles on Psychotic Disorders

JCP
Niacin-Induced Response in Early Psychosis
Original Research

July 21, 2025

The authors found that niacin-induced skin flushing response attenuation can serve as a valuable early marker for psychosis.
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JCP
VEGF and Other Biomarkers in Cognition of First Episode Psychosis
Original Research

July 9, 2025

VEGF levels were significantly higher in the first-episode psychosis group than in the control group. The preliminary results suggest that increase in VEGF might help preserve social cognition after...
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JCP
ECT for Psychotic vs Nonpsychotic Depression
Original Research

January 29, 2025

Patients with major depression with psychotic features had higher response rates to ECT than those without psychotic features and similar rates of adverse cognitive effects. After adjustment for confounders,...
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Recent PCC Articles on Psychotic Disorders

PCC
Psychosis Screening in Genetic Disorders
Letter to the Editor

December 4, 2025

The author discusses routine monitoring for the development of psychotic symptoms among individuals with rare genetic disorders that confer risk for psychosis.
PCC
Psychosis or Multiple System Atrophy?
Case Report

November 20, 2025

A 67-year-old woman presented with altered mental status, hallucinations, and hyperalgesia of the bilateral lower legs and was subsequently diagnosed with multiple system atrophy.
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PCC
Religious Preoccupation in Adolescence
Case Report

November 18, 2025

A 16-year-old boy developed new-onset psychosis of religious preoccupation and delusions.
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The latest news on Psychotic Disorders

Featured Psychotic Disorders Research

PCC
Access to Primary Care in First-Episode Psychosis
Original Research

October 2, 2025

Improving engagement in primary care is critical for young adults with first-episode psychosis to establish beneficial patterns of health care use and timely access to preventative care.
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JCP
Aripiprazole Lauroxil Initiation Regimens
Original Research

August 12, 2024

In separate studies of the two initiation methods, the numbers of people who had side effects were similar, and most side effects were mild.
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JCP
Clozapine Use and Specific Indications
Original Research

April 29, 2024

Clozapine initiation is uncommon in people with psychotic disorders who have experienced events suggesting clozapine is indicated, with even lower rates in Black and Hispanic patients.
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How Delusions Take Shape
news

January 22, 2026

A new study finds that early psychosis delusions emerge as emotionally grounded, embodied responses shaped by lived experience and relationships.
PCC
Cotard Syndrome in Schizophrenia
Case Report

January 8, 2026

A 42-year-old woman with schizophrenia and multiple prior hospitalizations presented with worsening psychosis and physical aggression toward her mother.
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JCP
Exercise Reduces Dysphoria in Clinical High-Risk for Psychosis: A Randomized Controlled Trial
Brief Report

January 7, 2026

Dysphoric mood was significantly reduced after an exercise intervention that included included high-impact treadmill interval training; there were no significant changes in other general symptoms.
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When Psychosis Strikes Overnight, Maybe It’s Encephalitis
news

January 5, 2026

Rapid-onset, atypical, or catatonic psychosis often points to encephalitis, not a psychiatric illness. And it demands urgent medical evaluation.
PCC
Transient Loss of Consciousness in an Adolescent with Pathological Intoxication
Case Report

January 1, 2026

This case of atypical symptoms in a 15-year-old boy underscores the need to differentiate pathological intoxication from seizures and psychiatric conditions, emphasizing alcohol abstinence.
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PCC
Machine Madness: A Case of Artificial Intelligence Psychosis
Case Report

December 30, 2025

A 41-year-old man with a history of substance-induced psychosis, developed symptoms of psychosis related to frequent occupational use of AI.
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Consensus Report on XT Use in Practice

Read the full report
Figure: Graphic promoting Consensus Report on Xanomeline-Trospium; colorful net design shown with JCP logo in lower left.

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