Systematic Review

Recently published articles about Systematic Review

JCP
Rechallenge of Lamotrigine After Rash: A Systematic Review
Systematic Review

December 31, 2025

Lamotrigine has been rechallenged safely in select cases, but it is critical to confirm that the initial rash did not have specific features of a severe rash in order...
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PCC
Psychiatric Adverse Effects of Hydroxychloroquine
Systematic Review

May 29, 2025

Hydroxychloroquine use is associated with various neuropsychiatric adverse effects, cognitive impairments, and behavioral changes.
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PCC
Exercise and Fibromyalgia Pain
Systematic Review

March 27, 2025

Adjunctive exercise therapies can be potentially beneficial in improving quality of life through reduction in pain catastrophizing.
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JCP
Inpatient Treatment of Suicidality
Systematic Review

January 8, 2025

Effective, rapid treatments that target suicidality in psychiatric inpatients are scarce in the existing literature and in clinical practice, underscoring the need for studies to identify and validate these...
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JCP
Efficacy and Safety of Memantine for Children and Adults with ADHD
Systematic Review

December 25, 2024

Although most studies involved small patient groups, memantine showed potential benefits in managing ADHD symptoms and had a favorable safety profile.
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PCC
Breast Cancer and Depression
Systematic Review

September 26, 2024

This scoping review explores depression prevalence, correlates, impact, and interventions in breast cancer patients, with a focus on the Indian context.
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Recent JCP Articles on Systematic Review

JCP
Predictors and Risk Factors of Treatment-Resistant Depression
Systematic Review

November 13, 2023

Early identification of individuals with major depressive disorder who are likely to develop treatment-resistant depression (TRD) is needed. This study reviewed the literature to identify and categorize the predictors...
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JCP
Therapeutic Reference Range for Olanzapine
Systematic Review

July 19, 2023

A therapeutic reference range of 20–40 ng/mL for oral and long-acting injectable olanzapine yields optimal treatment effects in schizophrenia spectrum disorders. Dose reduction is not needed above 40 ng/mL...
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JCP
GnRH Analogs in Premenstrual Dysphoric Disorder: Review and Practical Guideline
Systematic Review

June 21, 2023

This guideline provides screening tools, patient and provider handouts, and in-depth analysis of GnRH analogs and hormonal addback paradigms in PMDD.
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Recent PCC Articles on Systematic Review

PCC
Psychedelic Microdosing and Mental Health
Systematic Review

January 16, 2024

There is a growing body of evidence suggesting a positive correlation between psychedelic microdosing and improved mental well-being.
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PCC
Efficacy and Safety of Loxapine in Acute Agitation
Systematic Review

December 19, 2023

Loxapine was found to be more effective and faster regarding acute agitation control and was well-tolerated, with mildly or moderately severe adverse effects.
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PCC
Psychiatric Observation Unit Impact on ED Boarding
Systematic Review

November 7, 2023

Psychiatric observation units are mainly described within large urban general or academic hospital centers. Patients present predominantly with acute mental health crises or suicidality and are typically treated < 72...
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Featured Systematic Review Research

PCC
Intranasal Tapentadol Dependence
Case Report

February 26, 2026

The authors present 2 cases of intranasal tapentadol dependence marked by rapid tolerance and significant physical and psychological issues.
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PCC
Practice Relevance as the North Star: A Message From the Editor
Editorial

February 26, 2026

Dr Culpepper, Editor in Chief, outlines manuscript selection criteria for the PCC, prioritizing clinical relevance to primary care and frontline psychiatric settings, and thanks peer reviewers for their service.
PCC
Understanding the Impact of Moral Injury
Rounds in the General Hospital

February 26, 2026

Healing of moral injuries requires truth-telling, communal recognition, and moral repair—not just medication or cognitive restructuring.
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JCP
Diagnostic Assessment via Telehealth vs Face-to-Face
Systematic Review

September 16, 2024

Several small studies suggest that telehealth holds promise for psychiatric assessments, especially when in-person evaluations are not feasible.
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PCC
Ketogenic Diet Therapies in Pediatric Epilepsy
Systematic Review

June 25, 2024

In this systematic review, the authors evaluated the effects of a ketogenic diet on epilepsy in children and adolescents.
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PCC
Obsessive-Compulsive Symptoms in Dementia
Systematic Review

June 18, 2024

The authors assess the literature on neurobiological mechanisms of obsessive-compulsive symptoms in dementia patients to shed light on the similarities and differences between these symptoms in dementia and in...
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PCC
Impact of Theta Burst Stimulation on MS
Systematic Review

April 18, 2024

Theta burst stimulation interventions may hold promise in addressing specific multiple sclerosis symptoms, notably fatigue and spasticity.
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PCC
Therapist-Guided Versus Self-Guided CBT
Systematic Review

March 21, 2024

Results were positive for the use of internet-based cognitive-behavioral therapy and encouraging for new methods of guided therapy and the inclusion of technology.
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JCP
Systematic Review of the Effects of Cannabis and Cannabinoids in PTSD Symptoms and Symptom Clusters
Systematic Review

February 14, 2024

This review of 14 studies did not find major benefits of cannabinoids in improving overall PTSD symptoms, although some benefits in cluster B and E symptoms were seen. Risks...
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Consensus Report on XT Use in Practice

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Figure: Graphic promoting Consensus Report on Xanomeline-Trospium; colorful net design shown with JCP logo in lower left.

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