Incidents involving both a homicide and a suicide are rare and vary widely in terms of motive and circumstances. Read this study to learn about 8 classifications of homicide-suicides the authors developed using a large database.
Here, read about a 29-year-old woman who presented to our inpatient psychiatric facility for manic-like symptoms including pressured speech, flight of ideas, sexual preoccupations, and self-reported euphoria.
The authors of this letter to the editor discuss a study of the adult clinical trajectories of a cohort of adolescents diagnosed with conduct disorder after referral to an urgent psychiatry service using a retrospective record-linkage approach.
Intermittent explosive disorder (IED) is associated with intimate partner assault, the use of weapons to threaten others, and arrests. This behavior can be reduced through pharmacologic and psychosocial interventions. Learn about IED in this CME journal article.
Daily partner violence often occurs irregularly, making violence unpredictable. But the degree of unpredictability is a strong predictor of patient outcomes. Here, read about a 10-item scale designed to simplify assessment of violence irregularity.
In this letter to the editor, Dr Poulton comments on the recent article "Impact of Drug Adherence on Oppositional Defiant Disorder and Conduct Disorder Among Patients With Attention-Deficit/Hyperactivity Disorder" by Wang et al.
Given the limited efficacy and questionable safety profiles of current pharmacologic treatments of agitation in Alzheimer's disease (AD), the therapeutic potential of natural and synthetic cannabinoids are being explored in AD-related agitation. This meta-analysis reviews the efficacy and safety of these treatments.
Attention-deficit/hyperactivity disorder may be a precursor to oppositional defiant disorder and conduct disorder. Could better adherence to medication treatment for ADHD lower the chance that youths will later develop these other behavior disorders? This analysis of data from a Taiwanese national insurance database investigates that question.
Treatment-resistant aggressive behavior is commonly observed in psychiatric patients with psychosis, especially in state mental health institutions and prison systems with high health care and societal costs. Could dextromethorphan/quinidine be a potentially safe and tolerable alternative to conventional treatment regimens for treatment-resistant aggression and impulsive behavior in these patients? Read this retrospective case study to find out more.
Suicide and pollen levels have been linked in some prior research, yet no studies have actually examined the relationship between pollen levels and non-fatal self-directed violence. For the first time, a study looks at this intriguing association.
About 86% of the current US military force is male, and intimate partner violence among military veterans is a serious public health concern. This RCT is the first to compare treatment as usual with the Strength at Home Men's Program, a trauma-informed group intervention based on a social information processing model. See which worked better.
Baclofen, a French Exception, Seriously Harms Alcohol Use Disorder Patients Without Benefit
To the Editor: Dr Andrade’s analysis of the Bacloville trial in a recent Clinical and Practical Psychopharmacology column, in which he concluded that “individualized treatment with high-dose baclofen (30-300 mg/d) may be a useful second-line approach in heavy drinkers” and that “baclofen may be particularly useful in patients with liver disease,” deserves comment.1
First, Andrade failed to recall that the first pivotal trial of baclofen, ALPADIR (NCT01738282; 320 patients, as with Bacloville), was negative (see Braillon et al2).
Second, Dr Andrade should have warned readers that Bacloville’s results are most questionable, lacking robustness. Although he cited us,3 he overlooked the evidence we provided indicating that the Bacloville article4 was published without acknowledging major changes to the initial protocol, affecting the primary outcome. Coincidentally (although as skeptics, we do not believe in coincidence), the initial statistical team was changed when data were sold to the French pharmaceutical company applying for the marketing authorization in France. As Ronald H. Coase warned, “If you torture the data long enough, it will confess.”