XAll Individual Users: You may have noticed, we have just launched our new website. We will be adding more features over the upcoming weeks that you will like, so there may be a few hiccups along the way. If this is your first time visiting since our relaunch, please reset your password so you can still access our journals and CME activities that we have been providing for over 80 years. If you have any questions or comments please contact us at webadmin@psychiatrist.com.
XAll Individual Users: You may have noticed, we have just launched our new website. We will be adding more features over the upcoming weeks that you will like, so there may be a few hiccups along the way. If this is your first time visiting since our relaunch, please reset your password so you can still access our journals and CME activities that we have been providing for over 80 years. If you have any questions or comments please contact us at webadmin@psychiatrist.com.
Psyllium is often used to reduce constipation, but could it make a coadministered medication less effective? This report describes an unexpected interaction.
Supportive therapy is a practical and flexible psychosocial intervention that busy practitioners can use to help patients struggling emotionally with a medical illness. Learn more in this CME journal article.
Autoimmune encephalitis (AE) is a highly treatable neurologic condition that can cause psychosis. This study estimated the cost-effectiveness of routine screening for AE compared with clinically targeted screening in first-episode psychosis patients.
Autoimmune encephalitis (AE) is a highly treatable neurologic condition that can cause psychosis. This study estimated the cost-effectiveness of routine screening for AE compared with clinically targeted screening in first-episode psychosis patients.
Veterans of recent conflicts were often exposed to open burn pits used for solid waste disposal and thus suffer health consequences. Here, read about a veteran whose previous open burn pit exposure may place him at high risk for COVID-19 infection.
Cobalamin deficiency has hematologic, neurologic, and psychiatric sequelae. This report describes a patient with no prior psychiatric history but with past history of total gastrectomy who developed mania.
Why do some patients with HIV/AIDS experience a decrease in self-esteem after diagnosis while others do not? The authors of this study attempt to answer this question by investigating the self-esteem and defense mechanisms in HIV/AIDS patients.
The authors of this letter to the editor question the diagnosis of a patient in a case report previously published in The Primary Care Companion for CNS Disorders.
A 69-year-old woman with a history of depression presents with recent onset of cognitive symptoms and impairment in daily activities coupled with persistent atypical psychiatric symptoms and a poor response to treatment. Could she have a brain tumor?
Behavioral activation treatment for depression is effective for patients referred from primary care. Could it also be effective for PTSD as well? Read this article to find out more.
Baclofen, a French Exception, Seriously Harms Alcohol Use Disorder Patients Without Benefit
To the Editor: Dr Andrade’s analysis of the Bacloville trial in a recent Clinical and Practical Psychopharmacology column, in which he concluded that “individualized treatment with high-dose baclofen (30-300 mg/d) may be a useful second-line approach in heavy drinkers” and that “baclofen may be particularly useful in patients with liver disease,” deserves comment.1
First, Andrade failed to recall that the first pivotal trial of baclofen, ALPADIR (NCT01738282; 320 patients, as with Bacloville), was negative (see Braillon et al2).
Second, Dr Andrade should have warned readers that Bacloville’s results are most questionable, lacking robustness. Although he cited us,3 he overlooked the evidence we provided indicating that the Bacloville article4 was published without acknowledging major changes to the initial protocol, affecting the primary outcome. Coincidentally (although as skeptics, we do not believe in coincidence), the initial statistical team was changed when data were sold to the French pharmaceutical company applying for the marketing authorization in France. As Ronald H. Coase warned, “If you torture the data long enough, it will confess.”