Focus on Psychosis

Recently published articles about Focus on Psychosis

JCP
Effect of Adjuvant Metformin on Adherence to and Persistence of Treatment With SGAs in Nondiabetic Patients
Original Research

November 17, 2025

Use of metformin with second-generation antipsychotics (SGAs) was associated with improved adherence and persistence to SGAs at both 180- and 365-day follow-up in adults with Medicaid and commercial insurance.
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JCP
The Characteristics and Burden of Cognitive Impairments in Schizophrenia in the US
Original Research

August 11, 2025

Medical Expenditure Panel Survey data showed that over half of adults with schizophrenia report cognitive impairments, which were associated with higher healthcare costs and lower quality of life.
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JCP
Niacin-Induced Response in Early Psychosis
Original Research

July 21, 2025

The authors found that niacin-induced skin flushing response attenuation can serve as a valuable early marker for psychosis.
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JCP
VEGF and Other Biomarkers in Cognition of First Episode Psychosis
Original Research

July 9, 2025

VEGF levels were significantly higher in the first-episode psychosis group than in the control group. The preliminary results suggest that increase in VEGF might help preserve social cognition after...
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JCP
Cardiovascular Risk Factors and Second Generation Antipsychotics
Original Research

January 8, 2025

Despite well-documented cardiovascular disease (CVD) morbidity and mortality, CVD risks among people with severe mental illness who use antipsychotics are common and frequently untreated.
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JCP
Changes in Cognition in Patients With Schizophrenia
Meta-Analysis

September 25, 2024

Only marginal improvements in cognition were seen over time; the greatest were achieved for patients with an illness duration shorter than 10 years.
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Recent JCP Articles on Focus on Psychosis

JCP
Aripiprazole Lauroxil Initiation Regimens
Original Research

August 12, 2024

In separate studies of the two initiation methods, the numbers of people who had side effects were similar, and most side effects were mild.
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JCP
Emotional Neglect and Inflammatory Ratios in First-Episode Psychosis
Original Research

May 22, 2024

The authors examined the link between the immune system and childhood traumatic events in patients with first-episode psychosis.
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JCP
Concomitant LAIs and Time to Rehospitalization in Patients Receiving Clozapine
Original Research

May 1, 2024

Clozapine plus LAI antipsychotics was associated with lower risk of rehospitalization compared to both clozapine plus oral antipsychotics and clozapine monotherapy.
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Featured Focus on Psychosis Research

JCP
Clozapine Use and Specific Indications
Original Research

April 29, 2024

Clozapine initiation is uncommon in people with psychotic disorders who have experienced events suggesting clozapine is indicated, with even lower rates in Black and Hispanic patients.
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JCP
Severity of Antipsychotic-Induced Cervical Dystonia by Algorithm-Based Rating System
Original Research

April 15, 2024

Rater consensus data were compared with deviation angle data using AI-based deviation angle measurement technology. With the range of tilt angles found in the study, the authors propose a...
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JCP
Excess Mortality Associated With Schizophrenia
Original Research

September 13, 2023

Females, patients with connective tissue disorders, and those aged 20 years or younger were especially impacted by the effect of schizophrenia on increasing mortality.
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Consensus Report on XT Use in Practice

Figure: Graphic promoting Consensus Report on Xanomeline-Trospium; colorful net design shown with JCP logo in lower left.

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