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Letter to the Editor

Antipsychotic Medication and Diabetes Mellitusrs

Leslie L. Citrome, MD, MPH

Published: March 15, 2005

Article Abstract

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Sir: Spoelstra and colleagues1 assert that antipsychotic drugs may worsen metabolic control in type 2 diabetes mellitus and speculate from their pharmacoepidemiologic study that this worsening is probably due to β-cell toxicity. While there is general agreement that exposure to antipsychotic medications (and second-generation agents in particular) may be associated with an increased risk of diabetes mellitus,2 there are several problems regarding the authors’ interpretation of the data. First, a comparison group of those not taking antipsychotics is probably not comparable to a group taking these medications.

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