The Journal of
Clinical Psychiatry

Volume 87 • 2026 • 1

Editorial

Thank You to the JCP Community

J Clin Psychiatry 2026;87(1):25ed16293

Marlene P. Freeman, MD

Editorial

Psychotherapy: Integral to Clinical Psychiatry

J Clin Psychiatry 2026;87(1):26ed16341

Rachel C. Vanderkruik, PhD; John C. Markowitz, MD

Consensus Statement

Next-Step Treatment Options for Treatment-Resistant Depression: Insights From the Mayo Clinic Depression Center Panel

J Clin Psychiatry 2026;87(1):25cs16066

Matheus G. Marques, MD; Aysegul Özerdem, MD, PhD; Simon Kung, MD; Jennifer L. Vande Voort, MD; Hannah K. Betcher, MD; Melanie Gentry, MD; Marin Veldic, MD; Katherine M. Moore, MD; Paul E. Croarkin, DO, MS; Brandan K. Penaluna, MD, MBA; Stefanie Cavalcanti, MD; Mark A. Frye, MD; Balwinder Singh, MD, MS

Meta-Analysis

Effectiveness of Peer-Administered Interventions for Perinatal Depression or Anxiety: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

J Clin Psychiatry 2026;87(1):25r15805

Arooba Mansoor, MSc; Jaslyn Drage, BSc; Madisyn Campbell, BSc; Kian Yousefi Kousha, MSc; Sawayra Owais, MD, PhD; Emma A. van Reekum, MD; Ryan J. Van Lieshout, MD, PhD

Systematic Review

Rechallenge of Lamotrigine After Rash: A Systematic Review

J Clin Psychiatry 2026;87(1):25r15987

Hannah R. Riva, MD; Sabrina Zheng, BS; Nehaa Sohail, MBA; Sabrina A. Newman, MD; Patricia E. Ortiz, MD

Original Research

Innovation in Psychiatric Drug Development: A Quantitative Analysis of FDA-Approved Psychiatric Drugs, 2012–2024

J Clin Psychiatry 2026;87(1):25m16063

John Havlik, MD, MBA; Sayana Isaac; Caitlin Radovan; Michael J. Ostacher, MD, MPH; David Smith, MD; Taeho Greg Rhee, PhD

Original Research

Effect of Concurrent Metformin on Adherence to and Persistence of Treatment With Second-Generation Antipsychotics in Nondiabetic Patients

J Clin Psychiatry 2026;87(1):25m15808

Jerusha Daggolu, MD; Hua Chen, MD, PhD

Original Research

Trends in Benzodiazepine Prescribing to Adults in the United States: Results From the Medical Expenditure Panel Survey

J Clin Psychiatry 2026;87(1):25m16125

Mark Olfson, MD, MPH; Chandler McClellan, PhD; Samuel H. Zuvekas, PhD; Carlos Blanco, MD, PhD

Original Research

Effects of a Digital Multidomain Cognitive Intervention in Older People at High Risk of Dementia: A Randomized Clinical Trial

J Clin Psychiatry 2026;87(1):25m15860

Yuanjiao Yan, PhD; Xinying Lin, MM; Ying Lu, BS; Zixin Fang, MM; Xiaozhen Fu, MM; Shaobo Wu, MM; Bingjie Wei, MM; Zhengmin Wang, MM; Yunzhen Chen, MM; Zhi Chen, MM; Rong Lin, PhD; Hong Li, PhD

Original Research

Identifying Optimal Thresholds for Early Opioid Use Frequency in Predicting Buprenorphine Outcomes

J Clin Psychiatry 2026;87(1):25m16042

Victoria R. Votaw, PhD; Allen J. Bailey, PhD; Roger D. Weiss, MD; R. Kathryn McHugh, PhD

Original Research

Therapist-Delivered Video Therapy Habit Reversal Training for Body-Focused Repetitive Behaviors: Clinical Outcomes From a Large Real-World Sample of Youth and Adults

J Clin Psychiatry 2026;87(1):25m15834

Jamie D. Feusner, MD; Clare C. Beatty, MA; Christopher Murphy, BS; Patrick B. McGrath, PhD; Nicholas R. Farrell, PhD; Mia Nuñez, PhD; Nicholas Lume, BS; Reza Mohideen, BS; Larry Trusky, BS; Stephen M. Smith, BA; Andreas Rhode, PhD

Original Research

Geographic Differences in Cannabis Use and Cannabis Use Disorder in the US Veteran Population

J Clin Psychiatry 2026;87(1):25m16141

Annie-Lori Joseph Denk, PhD; Sarah B. True, MS; Melanie L. Hill, PhD; Ian C. Fischer, PhD; Peter Jongho Na, MD, MPH; Robert H. Pietrzak, PhD, MPH

How Many Criteria Should Be Required to Define the <strong><em>DSM-5</em></strong> Mixed Features Specifier in Depressed Patients?

Original Research

How Many Criteria Should Be Required to Define the DSM-5 Mixed Features Specifier in Depressed Patients?

J Clin Psychiatry 2026;87(1):24m15406

Mark Zimmerman, MD; Daniel Mackin, PhD

Original Research

Factors Associated With Revisiting the Emergency Department due to Suicidal Behavior in Children and Adolescents

J Clin Psychiatry 2026;87(1):25m15814

Ana María de Granda-Beltrán, MD; Inmaculada Peñuelas-Calvo, MD, PhD; María Taracena-Cuerda, MD; Jimena María Merayo-Cano, MD; Lidia Carrillo-Notario, BA; Paula Andrea Hidalgo Muñoz, BA; Hugo J. Bello, PhD; Roberto Rodríguez-Jiménez, MD, PhD; Enrique Baca-García, MD, PhD; Alejandro Porras-Segovia, MD, PhD

Original Research

Unwanted Intrusive Thoughts of Infant-Related Sexual Harm: Prevalence and Assessment of Safety

J Clin Psychiatry 2026;87(1):25m15985

Quincy M. Beck, ScB; Juliette Sachet, BKin; Claudia Cargnelli, BHSc; Bronwen Lathrop, BA, Sc; Fiona L. Challacombe, PhD; Nichole Fairbrother, PhD

Original Research

Latency to Long-Acting Injectable Antipsychotic Initiation and Psychiatric Hospitalization in First-Episode Schizophrenia

J Clin Psychiatry. 2026;87(1):25m16048

Sung Woo Joo, MD, PhD; Jungsun Lee, MD, PhD

Original Research

The Effects of Extended Cannabis Abstinence in Comorbid Posttraumatic Stress Disorder and Cannabis Use Disorder

J Clin Psychiatry 2026;87(1):25m16099

Justyne D. Rodas, MSc; Maryam Sorkhou, HBSc; Stefan Kloiber, MD; Tony P. George, MD; Ahmed N. Hassan, MD

Original Research

Suicidality in Postpartum Women With Unipolar and Bipolar Depression: A Secondary Analysis Comparing Self-Reported and Clinician Assessments

J Clin Psychiatry 2026;87(1):25m15923

Cindy L. Herrick, MA; Amy Yang, MS; Catherine S. Stika, MD; Katherine L. Wisner, MD, MS

Original Research

Targeting Intolerance of Uncertainty During Pregnancy: A Randomized Controlled Trial to Prevent Postpartum Anxiety Disorders

J Clin Psychiatry 2026;87(1):25m15979

Melissa Furtado, MSc, PhD; Benicio N. Frey, MD, PhD; Briar E. Inness, PhD; Randi E. McCabe, PhD; Sheryl M. Green, PhD

Original Research

Triple Network Model–Based Functional Dysconnectivity in Young People With Major Affective Disorders With or Without Current Suicidal Ideation

J Clin Psychiatry 2026;87(1):25m15906

Wei-Sheng Huang, MD; Ju-Wei Hsu, MD; Li-Kai Cheng, PhD; Li-Chi Chen, MD; Ya-Mei Bai, MD, PhD; Li-Fen Chen, PhD; Pei-Chi Tu, MD, PhD; Mu-Hong Chen, MD, PhD

Original Research

Lack of Generalizability of PTSD Treatment Trials: The Recent Brexpiprazole-Sertraline Trials as an Example

J Clin Psychiatry 2026;87(1):25m15921

Mark Zimmerman, MD; Matthew Snyder, BS

Original Research

HIV Diagnosis and Preexposure Prophylaxis (PrEP) Prescription Among Commercially Insured Persons With Bipolar Disorder

J Clin Psychiatry 2026;87(1):25m15949

Samuel R. Bunting, MD, MSHA; Max J. Hyman, BA; Aniruddha Hazra, MD

Original Research

Obstetric Outcomes With Second-Generation Long-Acting Injectable Versus Oral Antipsychotics

J Clin Psychiatry 2026;87(1):25m16033

Farah Khorassani, PharmD, BCPP; Gemma Espejo, MD; Kelly C. Lee, PharmD, MAS, BCPP, FCCP, FASHP

Original Research

Valproic Acid Use Trends, Patterns, and Predictors in Females of Reproductive Age in the United States

J Clin Psychiatry 2026;87(1):25m16009

Nina Vadiei, PharmD, BCPP; Julianne A. Mercer, PharmD; Bernadette Cornelison, PharmD, MS, BCPS; David R. Axon, PhD, MPharm, MS; Grace C. Lee, PharmD, PhD

Original Research

Risk Factors for Suicide Attempts and Psychiatric Hospitalization Among Brazilian Health Care Professionals

J Clin Psychiatry 2026;87(1):25m15858

Rodolfo Furlan Damiano, MD, PhD; Marianna de Abreu Costa, MD, PhD; Carolina Blaya Dreher, MD, PhD; Craig J. Bryan, PsyD, ABPP; Eurípedes Constantino Miguel, MD, PhD; Marcelo Fleck, MD, PhD; Gisele Gus Manfro, MD, PhD; Giovanni Abrahão Salum, MD, PhD

Commentary

Benzodiazepines as Special Risk Medications

J Clin Psychiatry 2026;87(1):26com16314

Edward K. Silberman, MD

Commentary

Gender-Affirming Perinatal Psychiatry for Transgender and Gender Diverse People

J Clin Psychiatry 2026;87(1):25com15907

Marija Kamceva, MD; Ruchita S. Pendse, MD; Alex S. Keuroghlian, MD

Commentary

MAOI Antidepressants: A History Being Rewritten

J Clin Psychiatry 2026;87(1):25com16111

Vincent Van den Eynde, LLM; Chittaranjan Andrade, MD; Michael Berk, MD, PhD; Simeon Shalom Feinberg, MD; Scott Freeman, MD; David Nutt, MD, PhD; Gordon Parker, MD, PhD; Elliott Richelson, MD, PhD; Robert Rubin, MD, PhD; Eric Ruhe, MD, PhD; Stephen Stahl, MD, PhD; Allan Young, MD, PhD; Peter Kenneth Gillman, MD

Commentary

The Goldilocks Problem: Balancing Internal Validity With Generalizability in Clinical Trials

J Clin Psychiatry 2026;87(1):25com16224

Lori L. Davis, MD

Commentary

Precision Medicine for Suicide Prevention: It’s Time to Take the Next Step

J Clin Psychiatry 2026;87(1):25com16004

Alejandro Interian, PhD; Nathan A. Kimbrel, PhD; Marianne S. Goodman, MD; Joseph I. Constans, PhD; Steven K. Dobscha, MD; Mark Ilgen, PhD; Richard R. Owen, MD; Susan M. Strickland, PhD, LCSW; Brian P. Marx, PhD

Clinical and Practical Psychopharmacology

Pregabalin in Pregnancy: Major Congenital Malformations, Other Birth Outcomes, and Neurodevelopmental Outcomes

J Clin Psychiatry. 2026;87(1):25f16279

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

The E-Value in Regression: A Useful, Simple, Easily Understood, and Easily Applied Statistic

J Clin Psychiatry 2026;87(1):26f16324

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Gestational Exposure to Antidepressants and Neurodevelopmental Disorders in Offspring

J Clin Psychiatry 2026;87(1):25f16226.

Chittaranjan Andrade, MD

ASCP Corner

Rethinking Amisulpride: Could N-Methylation Result in a New and Even Better Antipsychotic?

J Clin Psychiatry 2026;87(1):25ac16295

John M. Kane, MD; Christoph U. Correll, MD

Brief Report

Dissociative Subtype of Posttraumatic Stress Disorder in US Military Veterans: Prevalence, Correlates, and Clinical Characteristics

J Clin Psychiatry 2026;87(1):25br15977

Brienna M. Fogle, MA, LPA; Ian C. Fischer, PhD; Peter J. Na, MD, MPH; Robert H. Pietrzak, PhD, MPH

Brief Report

Exercise Reduces Dysphoria in Clinical High Risk for Psychosis: A Randomized Controlled Trial

J Clin Psychiatry 2026;87(1):25br16079

Katherine S. F. Damme, PhD; Vijay A. Mittal, PhD

Brief Report

Retired US Military Veterans and Suicide Risk

J Clin Psychiatry 2026;87(1):25br15914

Chandru Ravindran, MS; Sybil W. Morley, MPH; Mark E. Overberg, MBA; Brady M. Stephens, MS

Case Series

Efficacy and Tolerability of Esketamine Augmented With Dextromethorphan/Bupropion for Treatment-Resistant Depression: A Case Series

J Clin Psychiatry 2026;87(1):25cr16082

Joshua C. Eloge, MD; Taymaz Joneydian, MD; Kirk McCall, MD; Ian Mackey, MS, PA-C; John Zajecka, MD

Letter to the Editor

Urological Commentary on Ketamine-Associated Uropathy

J Clin Psychiatry 2026;87(1):25lr16229

Asem Abdelrahman, MBChB, MRCS

Letter to the Editor

Ketamine-Associated Uropathy in Therapeutic Contexts: Reply to Abdelrahman

J Clin Psychiatry 2026;87(1):25lr16229a

Chittaranjan Andrade, MD

Letter to the Editor

Rationale for Clozapine Trial

J Clin Psychiatry 2026;87(1):25lr16256

Jeffrey A. Mattes, MD

Letter to the Editor

The Position of Clozapine in Patients With Treatment-Resistant Schizophrenia: Reply to Mattes

J Clin Psychiatry 2026;87(1):25lr16256a

Chittaranjan Andrade, MD

Letter to the Editor

Racemic Ketamine vs Esketamine in Treatment-Resistant Depression: The Overlooked Role of Arketamine

J Clin Psychiatry 2026;87(1):25lr16166

Yunfei Tan, MD, PhD; Kenji Hashimoto, PhD

Letter to the Editor

Exposure Therapy for Perinatal OCD: Navigating Evidence and Discomfort

J Clin Psychiatry 2026;87(1):25l16145

Rachel Vanderkruik, PhD, MSc, CMPC; Martha J. Falkenstein, PhD; Jonathan S. Abramowitz, PhD

Letter to the Editor

Burnout in Psychiatric Doctors Before and After COVID-19: A Critical Commentary

J Clin Psychiatry 2026;87(1):25lr16171

Hinpetch Daungsupawong, PhD; Viroj Wiwanitkit, MD

Letter to the Editor

Reframing the Discussion on Finasteride and Neuropsychiatric Safety: A Call for Balanced Interpretation

J Clin Psychiatry 2026;87(1):25lr16181

Samuel Tringali, DO; Joseph Tringali, DO

Letter to the Editor

Finasteride-Induced Neuropsychiatric Reactions: No Room for Complacency

J Clin Psychiatry 2026;87(1):25lr16181a

Mayer Brezis, MD, MPH

Volume 87 • 2026 • 1

Editorial

Thank You to the JCP Community

Psychotherapy: Integral to Clinical Psychiatry

Consensus Statement

Next-Step Treatment Options for Treatment-Resistant Depression: Insights From the Mayo Clinic Depression Center Panel

Meta-Analysis

Effectiveness of Peer-Administered Interventions for Perinatal Depression or Anxiety: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Systematic Review

Rechallenge of Lamotrigine After Rash: A Systematic Review

Original Research

Innovation in Psychiatric Drug Development: A Quantitative Analysis of FDA-Approved Psychiatric Drugs, 2012–2024

Effect of Concurrent Metformin on Adherence to and Persistence of Treatment With Second-Generation Antipsychotics in Nondiabetic Patients

Trends in Benzodiazepine Prescribing to Adults in the United States: Results From the Medical Expenditure Panel Survey

Effects of a Digital Multidomain Cognitive Intervention in Older People at High Risk of Dementia: A Randomized Clinical Trial

Identifying Optimal Thresholds for Early Opioid Use Frequency in Predicting Buprenorphine Outcomes

Therapist-Delivered Video Therapy Habit Reversal Training for Body-Focused Repetitive Behaviors: Clinical Outcomes From a Large Real-World Sample of Youth and Adults

Geographic Differences in Cannabis Use and Cannabis Use Disorder in the US Veteran Population

How Many Criteria Should Be Required to Define the DSM-5 Mixed Features Specifier in Depressed Patients?

Factors Associated With Revisiting the Emergency Department due to Suicidal Behavior in Children and Adolescents

Unwanted Intrusive Thoughts of Infant-Related Sexual Harm: Prevalence and Assessment of Safety

Latency to Long-Acting Injectable Antipsychotic Initiation and Psychiatric Hospitalization in First-Episode Schizophrenia

The Effects of Extended Cannabis Abstinence in Comorbid Posttraumatic Stress Disorder and Cannabis Use Disorder

Suicidality in Postpartum Women With Unipolar and Bipolar Depression: A Secondary Analysis Comparing Self-Reported and Clinician Assessments

Targeting Intolerance of Uncertainty During Pregnancy: A Randomized Controlled Trial to Prevent Postpartum Anxiety Disorders

Triple Network Model–Based Functional Dysconnectivity in Young People With Major Affective Disorders With or Without Current Suicidal Ideation

Lack of Generalizability of PTSD Treatment Trials: The Recent Brexpiprazole-Sertraline Trials as an Example

HIV Diagnosis and Preexposure Prophylaxis (PrEP) Prescription Among Commercially Insured Persons With Bipolar Disorder

Obstetric Outcomes With Second-Generation Long-Acting Injectable Versus Oral Antipsychotics

Valproic Acid Use Trends, Patterns, and Predictors in Females of Reproductive Age in the United States

Risk Factors for Suicide Attempts and Psychiatric Hospitalization Among Brazilian Health Care Professionals

Commentary

Benzodiazepines as Special Risk Medications

Gender-Affirming Perinatal Psychiatry for Transgender and Gender Diverse People

MAOI Antidepressants: A History Being Rewritten

The Goldilocks Problem: Balancing Internal Validity With Generalizability in Clinical Trials

Precision Medicine for Suicide Prevention: It’s Time to Take the Next Step

Clinical and Practical Psychopharmacology

Pregabalin in Pregnancy: Major Congenital Malformations, Other Birth Outcomes, and Neurodevelopmental Outcomes

The E-Value in Regression: A Useful, Simple, Easily Understood, and Easily Applied Statistic

Gestational Exposure to Antidepressants and Neurodevelopmental Disorders in Offspring

ASCP Corner

Rethinking Amisulpride: Could N-Methylation Result in a New and Even Better Antipsychotic?

Brief Report

Dissociative Subtype of Posttraumatic Stress Disorder in US Military Veterans: Prevalence, Correlates, and Clinical Characteristics

Exercise Reduces Dysphoria in Clinical High Risk for Psychosis: A Randomized Controlled Trial

Retired US Military Veterans and Suicide Risk

Case Series

Efficacy and Tolerability of Esketamine Augmented With Dextromethorphan/Bupropion for Treatment-Resistant Depression: A Case Series

Letter to the Editor

Urological Commentary on Ketamine-Associated Uropathy

Ketamine-Associated Uropathy in Therapeutic Contexts: Reply to Abdelrahman

Rationale for Clozapine Trial

The Position of Clozapine in Patients With Treatment-Resistant Schizophrenia: Reply to Mattes

Racemic Ketamine vs Esketamine in Treatment-Resistant Depression: The Overlooked Role of Arketamine

Exposure Therapy for Perinatal OCD: Navigating Evidence and Discomfort

Burnout in Psychiatric Doctors Before and After COVID-19: A Critical Commentary

Reframing the Discussion on Finasteride and Neuropsychiatric Safety: A Call for Balanced Interpretation

Finasteride-Induced Neuropsychiatric Reactions: No Room for Complacency

Consensus Report on XT Use in Practice

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