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The Journal of
Clinical Psychiatry
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The Journal of Clinical Psychiatry

Letter to the Editor July 21, 2009

Aripiprazole Treatment of Risperidone-Induced Hyperprolactinemia

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J Clin Psychiatry 2009;70(7):1058-1059

Article Abstract

Letter to the Editor

Sir: Hyperprolactinemia is a well-recognized complication
of some antipsychotic agents that results from the blocking of
dopamine-2 (D2) receptors in the anterior pituitary. Aripiprazole,
a potent partial agonist of the D2 receptors, inhibits spontaneous
prolactin release from isolated anterior pituitary slices. Clinically,
switching to aripiprazole monotherapy resolves antipsychoticinduced
hyperprolactinemia.

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