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Letter to the Editor

Asymptomatic QTc Prolongation During Coadministration of Aripiprazole and Haloperidol

Roberto Leo, MD, FACP; Cinzia Razzini, MD; Giorgio Di Lorenzo, MD; Francesco Bianchi, MD; Manfredi Tesauro, MD; Marco Zanasi, MD; Alberto Siracusano, MD; and Francesco Romeo, MD, FACC, FESC

Published: February 14, 2008

Article Abstract

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Sir: Several non-antiarrhythmic drugs, including antipsychoticagents, have been shown to prolong cardiac repolarization,predisposing to torsades de pointes ventricular tachycardiaand sudden cardiac death.1 However, it is known that severalrisk factors may prolong QT interval, even in patients with anapparently normal baseline electrocardiogram (ECG).2 Psychoactivepolytherapy has to be included in these risk factorsdue to pharmacokinetic and pharmacodynamic interactions.3

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Volume: 69

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