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Letter to the Editor

Bupropion-Tranylcypromine Combination for Treatment-Refractory Depression

Joseph M. Pierre and Michael J. Gitlin

Published: November 30, 2000

Article Abstract

Letter to the Editor

Sir: We report the safe and successful use of combined bupropion
and tranylcypromine in a case of treatment-refractory

Case report. Ms. A, a 27-year-old woman with chronic major
depression (DSM-III-R criteria), was treated in 1990 at age
17 with imipramine up to 150 mg/day. In March 1994, after a
suicide attempt by imipramine overdose, paroxetine, 20 mg/day,
replaced imipramine. On paroxetine, 30 mg/day, and amitriptyline,
50 mg q.h.s., she experienced only mild improvement at
6 months.

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