This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Letter to the Editor

A Case of Delirium and Subsequent Pancytopenia Associated With the Oral Loading of Valproic Acid

Beang-Jin Chae, MD, and Byung-Jo Kang, MD

Published: June 15, 2005

Article Abstract

Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: Some studies have shown that the oral loading of valproicacid or divalproex sodium is most likely safe and leads tomore rapid antimanic effects than standard titration of theseagents.1-4 Although there are some case reports of delirium5,6 orpancytopenia7-12 associated with valproic acid, as far as weknow, serial acute adverse effects such as delirium and pancytopeniaresulting from the oral loading of valproic acid have not yet been reported. We present a case in which manic symptomswere relieved rapidly with the oral loading of valproic acid, butdelirium and subsequent pancytopenia developed as acute, severeadverse effects.’ ‹

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Volume: 66

Quick Links: