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Letter to the Editor

A Cautionary Note When Using Zonisamide in Youths: A Case Report of Association With Toxic Epidermal Necrolysis

Kevin D. Majeres, MD, and Trisha Suppes, MD, PhD

Published: December 15, 2004

Article Abstract

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Sir: Zonisamide is a third-generation sulfonamide anticonvulsant indicated for treatment of partial seizures. As with other anticonvulsants, it has shown efficacy in treating bipolar disorder in adults1 and, unlike other agents, does not appear to cause weight gain. Zonisamide is contraindicated in patients with known sulfa allergies due to the risk of developing a medicallyserious rash.

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